Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model [1] [2]. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which is able to be used for the research of solid tumors [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
5 mg | In stock | $ 76.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 622.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model [1] [2]. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which is able to be used for the research of solid tumors [3]. |
In vitro | IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in NIH3T3 mouse fibroblast cells in a dose- and time-dependent manner [1]. IM156 does not affect the expression of key factors involved in glucose homeostasis like glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1) [1]. Western Blot Analysis [1] Cell Line: NIH3T3 cells Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM Incubation Time: 4 hours Result: Significantly increased the AMPK phosphorylation rate. |
In vivo | IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity [1]. IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety [2]. IM156 markedly attenuates the aging-induced decline in novel object recognition memory and spatial working memory [2]. IM156 markedly increases AMPK activation in the hippocampus of aged mice [2]. Animal Model: C57BL/6J mice (young group/12-16 weeks, old groups/20-22 months) [2] Dosage: 50 mg/kg Administration: Oral administration (drinking water), for 2 months Result: Attenuated age-related cognitive decline. |
Molecular Weight | 315.29 |
Formula | C13H16F3N5O |
CAS No. | 1422365-93-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (87.22 mM), The compound is unstable in solution and is recommended to be prepared and used immediately.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IM156 1422365-93-2 Apoptosis OXPHOS IM 156 IM-156 inhibitor inhibit