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IM156

Catalog No. T8532   CAS 1422365-93-2

IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model [1] [2]. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which is able to be used for the research of solid tumors [3].

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IM156 Chemical Structure
IM156, CAS 1422365-93-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 33.00
5 mg In stock $ 76.00
10 mg In stock $ 122.00
25 mg In stock $ 198.00
50 mg In stock $ 372.00
100 mg In stock $ 622.00
1 mL * 10 mM (in DMSO) In stock $ 84.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model [1] [2]. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which is able to be used for the research of solid tumors [3].
In vitro IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in NIH3T3 mouse fibroblast cells in a dose- and time-dependent manner [1]. IM156 does not affect the expression of key factors involved in glucose homeostasis like glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1) [1]. Western Blot Analysis [1] Cell Line: NIH3T3 cells Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM Incubation Time: 4 hours Result: Significantly increased the AMPK phosphorylation rate.
In vivo IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity [1]. IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety [2]. IM156 markedly attenuates the aging-induced decline in novel object recognition memory and spatial working memory [2]. IM156 markedly increases AMPK activation in the hippocampus of aged mice [2]. Animal Model: C57BL/6J mice (young group/12-16 weeks, old groups/20-22 months) [2] Dosage: 50 mg/kg Administration: Oral administration (drinking water), for 2 months Result: Attenuated age-related cognitive decline.
Molecular Weight 315.29
Formula C13H16F3N5O
CAS No. 1422365-93-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (87.22 mM), The compound is unstable in solution and is recommended to be prepared and used immediately.

TargetMolReferences and Literature

1. Son J , Cho Y W , Woo Y J , et al. Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8 + T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection[J]. Immune Network, 2019, 19(2). 2. Said Izreig, Alexandra Gariepy, Irem Kaymak, et al. Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment.Cell Rep Med. 2020 May 19;1(2):100014.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Preclinical Compound Library Orally Active Compound Library Bioactive Compound Library Anti-Lung Cancer Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Apoptosis Compound Library Mitochondria-Targeted Compound Library Anti-Cancer Compound Library

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Keywords

IM156 1422365-93-2 Apoptosis OXPHOS IM 156 IM-156 inhibitor inhibit

 

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