permeability — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2721	Digitonin		Others
	Digitonin is a natural product of the glycoside family and is a detergent. Digitonin has antitumor activity, binds to cholesterol molecules to increase the permeability of cell membranes, and is active in the cleavage of...		Others
T8844	Diflapolin		Others , FLAP , Epoxide Hydrolase
	Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.		Others , FLAP , Epoxide Hydrolase
T4701	Diclofop-methyl		Others
	Diclofop-methyl is used as the active ingredient in many herbicides that are used to control weed growth in plants such as wheat and wild oats.		Others
T11014	DFP00173		Aquaporin
	DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous AQP subtypes AQP7 and AQP9, DFP00173 is selective for AQP3.		Aquaporin
T10760	Ceramides Mixture		Telomerase
	Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activ...		Telomerase
T2009	SB-3CT		MMP
	SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM).		MMP
T8490	Butoconazole	1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole	Antifungal
	Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent		Antifungal
T5194	SPHINX31		Serine/threonin kinase
	SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).		Serine/threonin kinase
T2670	ML167	NCGC00188654,CID44968231	DYRK , CDK
	ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.		DYRK , CDK
T2456	Tivozanib	AV-951,KRN951	VEGFR , PDGFR , Ephrin Receptor
	Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities.		VEGFR , PDGFR , Ephrin Receptor
T23426	TC-A 2317 hydrochloride		Others , Aurora Kinase
	TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.		Others , Aurora Kinase
T37890L	GLP-1(28-36)amide acetate	GLP-1(28-36)amide acetate(1225021-13-5 Free base)	Antioxidant , Glucagon Receptor
	GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.		Antioxidant , Glucagon Receptor
T15157	Dodecanoylcarnitine	Lauroylcarnitine	Endogenous Metabolite
	Dodecanoylcarnitine ((-)-Lauroylcarnitine) has been associated with disturbances in fatty acid oxidation, and the use of Dodecanoylcarnitine resulted in an increase in the permeability of salmon calcitonin.		Endogenous Metabolite
T19562	Polyethylene glycol 12-hydroxystearate	Solutol HS-15	Others
	Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.		Others
T15241	ER-000444793		Others , Mitochondrial Metabolism
	ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).		Others , Mitochondrial Metabolism
TN1990	Norathyriol		Akt , DNA/RNA Synthesis , AMPK , PPAR
	Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.		Akt , DNA/RNA Synthesis , AMPK , PPAR
T18988L	FITC-Dextran (MW 4000)	FITC-Dextran (60842-46-8 MW 4000)	Others
	FITC-Dextran (MW 4000) is a marker composed of fluorescein isothiocyanate conjugated to 4 kDa dextran, widely used in microcirculation and cell permeability studies.		Others
TN1048	Cnidilin	Knidilin
	Cnidilin (Knidilin) is found in association with Angelica dahurica roots, has high BBB permeability and has pharmacokinetic potential in the treatment of CNS disorders.
T7486	Imeglimin hydrochloride	EMD 387008 hydrochloride	Reactive Oxygen Species , Mitochondrial Metabolism
	Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.		Reactive Oxygen Species , Mitochondrial Metabolism
T68030	Acitemate	Chinoin 123	Others
	Acitemate(Chinoin 123) has an inhibitory effect on atherosclerosis and reduces the permeability of the aorta in rabbits fed a hyperlipidemic diet, which can be used to study atherosclerosis.		Others