Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 243.00 | |
50 mg | In stock | $ 405.00 | |
100 mg | In stock | $ 590.00 | |
500 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 64.00 |
Description | Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. |
Targets&IC50 | FLAP:20 nM, Others:20 nM |
In vitro | Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC50=20?nM). |
In vivo | Diflapolin (1-10 mg/kg; i.p.; 30?min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments |
Molecular Weight | 458.36 |
Formula | C22H17Cl2N3O2S |
CAS No. | 724453-98-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 84mg/mL (183.26mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Diflapolin 724453-98-9 Immunology/Inflammation Metabolism Others FLAP Epoxide Hydrolase diseases Inhibitor permeability neutrophil vascular infiltration 5-LO activating protein inflammation cysteinyl-LTs inhibit inhibitor