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Norathyriol

Catalog No. TN1990 CAS 3542-72-1

Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.

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Norathyriol, CAS 3542-72-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
Targets&IC50	PPARβ:102.4 μM (IC50), PPARα:92.8 μM (IC50), PPARγ:153.5 μM (IC50)
In vitro	Normal or IR L6 myotubes were incubated with Norathyriol (2.5 - 10 μM, 0.625 - 2.5 μM), mangiferin (10 - 40 μM, 2.5 - 10 μM) or rosiglitazone (20 μM) and/or 0.05 nM insulin for 24 h, respectively. The glucose consumption was assessed using the glucose oxidase method. Immunoblotting was performed to detect protein kinase B (PKB/Akt) and AMP-activated protein kinase (AMPK) phosphorylation in L6 myotubes cells. Norathyriol and mangiferin treatment alone increased the glucose consumption 61.9 and 56.3%, respectively, in L6 myotubes and made additional increasing with 0.05 nM insulin. In IR L6 myotubes, Norathyriol treatment made increasing with or without insulin, mangiferin treatment also made increasing but only when co-treated with insulin. Immunoblotting results showed that Norathyriol and mangiferin produced an increase of 1.9 - and 1.8-fold in the phosphorylation levels of the AMPK, but not in Akt[1]

Molecular Weight	260.2
Formula	C13H8O6
CAS No.	3542-72-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 65 mg/ml (249.81 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase.Pharm Biol. 2014 Jan;52(1):68-73.

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Keywords

Norathyriol 3542-72-1 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Metabolism PI3K/Akt/mTOR signaling DNA/RNA Synthesis AMPK Akt PPAR Natural Antioxidant Peroxisome proliferator-activated receptors anti-bacterial inhibit anticancer α-glucosidase anti-inflammatory Mangiferitin antimicrobial Glucosidase metabolite Inhibitor Mangifera inhibitor

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