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Butoconazole

Catalog No. T8490 CAS 64872-76-0

Synonyms: 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole

Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Butoconazole, CAS 64872-76-0

Pack Size	Availability	Price/USD	Quantity
25 mg	4-6 weeks	$ 81.00
1 mL * 10 mM (in DMSO)	4-6 weeks	$ 50.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Purity: 99.65%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent
In vivo	Butoconazole is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended[1].Butoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis[2].

Synonyms	1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole
Molecular Weight	411.78
Formula	C19H17Cl3N2S
CAS No.	64872-76-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 77 mg/ml(187 mM)

References and Literature

1. Walker K A M , Braemer A C , Hitt S , et al. 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent[J]. Journal of Medicinal Chemistry, 1978, 21(8):840-843. 2. Brown D , Henzl M R , Kaufman R H . Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group[J]. Journal of Reproductive Medicine, 1999, 44(11):933-938.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Infection Compound Library Anti-Fungal Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Butoconazole 64872-76-0 Microbiology/Virology Antifungal conversion Inhibitor cell ergosterol osmotic 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole inhibit lanosterol Fungal permeability inhibitor

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