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Polyethylene glycol 12-hydroxystearate

Catalog No. T19562 CAS 61909-81-7

Synonyms: Solutol HS-15

Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.

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Polyethylene glycol 12-hydroxystearate Chemical Structure

Polyethylene glycol 12-hydroxystearate, CAS 61909-81-7

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Purity: mixture

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.

In vitro

Solutol HS-15 promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Solutol HS-15, relative to the respective control, at 4°C. Solutol HS-15 treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control).

Synonyms	Solutol HS-15
Molecular Weight	344.536
Formula	C20H40O4
CAS No.	61909-81-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 100 mg/mL, Sonication is recommended.

H2O: 25 mg/mL, Sonication is recommended.

References and Literature

1. Shubber S, et al. Mechanism of mucosal permeability enhancement of CriticalSorb? (Solutol? HS15) investigated in vitro in cell cultures. Pharm Res. 2015 Feb;32(2):516-27.

Citations

1. Xu L, He D, Wu Y, et al. Tanshinone IIA inhibits cardiomyocyte apoptosis and rescues cardiac function during doxorubicin-induced cardiotoxicity by activating the DAXX/MEK/ERK1/2 pathway. Phytomedicine. 2022: 154471.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Polyethylene glycol 12-hydroxystearate 61909-81-7 Others Inhibitor inhibit Solutol Polyethylene glycol 12 hydroxystearate Solutol HS-15 Polyethylene glycol 12hydroxystearate HS-15 inhibitor

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