neuroblastoma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16350	NSC-87877		Apoptosis , Phosphatase
	NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).		Apoptosis , Phosphatase
T1841	UNC0379		Histone Methyltransferase
	UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.		Histone Methyltransferase
T6911	NSC-87877 disodium	NSC87877	Apoptosis , Phosphatase
	NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduce...		Apoptosis , Phosphatase
T8596	Ceefourin 1		MRP
	Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.		MRP
T12165	NAChR agonist 1	DUN71755	AChR
	nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.		AChR
T11908	LY2365109 hydrochloride		GlyT
	LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.		GlyT
T6609	NMS-E973		HSP
	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.		HSP
T6708	Tolcapone	Tasmar,Ro 40-7592	Apoptosis , Beta Amyloid , Transferase
	Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.		Apoptosis , Beta Amyloid , Transferase
T0412	Idebenone	CV-2619	Apoptosis , Antioxidant , Mitochondrial Metabolism
	Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC).		Apoptosis , Antioxidant , Mitochondrial Metabolism
T9240	Sulfopin	Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-	Others
	Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo.		Others
T12134	MYCMI-6	NSC354961	Apoptosis , c-Myc
	MYCMI-6 (NSC-354961) is a potent and selective inhibitor of endogenous MYC:MAX protein interactions，reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without seve...		Apoptosis , c-Myc
T1967	AZD-3463	ALK/IGF1R inhibitor	Apoptosis , IGF-1R , ALK , Autophagy
	AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.		Apoptosis , IGF-1R , ALK , Autophagy
T6611	NSC697923	2-[(4-methylphenyl)sulfonyl]-5-nitrofuran	E1/E2/E3 Enzyme
	NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct me...		E1/E2/E3 Enzyme
T3061	Lorlatinib	PF-6463922,PF-06463922,Loratinib	Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
	Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.		Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
T29541	AC265347	AC-265347	CaSR
	AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity that inhibits neuroblastoma tumour growth by inducing differentiation.AC265347 can be used to stud...		CaSR
T1166	Ellipticine	NSC 71795,Elliptisine	Topoisomerase
	Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-6...		Topoisomerase
T3787	Didymin	Isosakuranetin-7-O-rutinoside,Neoponcirin	Apoptosis , Others
	Didymin (Neoponcirin) has antioxidant property. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma, may used for neuroblastoma therapy. Didymin may be a potential therapeutic molecule fo...		Apoptosis , Others
T77495	WDR5-IN-6		JAK
	WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6 exhibits potent antitumor activity and inhibits cell proliferati...		JAK
T3203	Methyl 13-cis-4-Oxoretinoate	13-cis-4-Oxo-retinoic acid Methyl Ester,4-Keto 13-cis-Retinoic Acid Methyl Ester	Others
	Methyl 13-cis-4-Oxoretinoate (13-cis-4-Oxo-retinoic acid Methyl Ester) is a retinoic acid metabolite in neuroblastoma.		Others
T3S1589	Notoginsenoside Fa		Others
	1. Notoginsenosides Fa and R4 show significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells.		Others