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Ceefourin 1

Catalog No. T8596 CAS 315702-40-0

Ceefourin 1 is a highly selective multidrug resistance protein 4 (<a href="/target/MRP" style="display: inline; color: #c13a36">MRP</a>4) inhibitor.

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Ceefourin 1, CAS 315702-40-0

Pack Size	Availability	Price/USD
2 mg	In stock	$ 59.00
5 mg	In stock	$ 85.00
10 mg	In stock	$ 126.00
25 mg	In stock	$ 263.00
50 mg	In stock	$ 409.00
100 mg	In stock	$ 774.00
200 mg	In stock	$ 1,161.00

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Purity: 98.4%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.

In vitro

Ceefourin 1 and Ceefourin 2, that inhibit transport of a broad range of MRP4 substrates, yet are highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein;?BCRP) and MRP1 (multidrug resistance protein 1;?ABCC1).?Both compounds are more potent MRP4 inhibitors in cellular assays than the most widely used inhibitor, MK-571, requiring lower concentrations to effect a comparable level of inhibition.?Furthermore, Ceefourin 1 and Ceefourin 2 have low cellular toxicity, and high microsomal and acid stability.

Molecular Weight	294.41
Formula	C11H10N4S3
CAS No.	315702-40-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cheung L , Flemming C L , Watt F , et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)[J]. Biochemical Pharmacology, 2014, 91(1):97-108.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

Related Products

Related compounds with same targets

Sophoraisoflavone A PU23 LY402913 Ceefourin 1 LY-402913 Estriol Perindoprilat Gramicidin

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ceefourin 1 315702-40-0 Immunology/Inflammation MRP P-glycoprotein chemosensitizers inhibit efflux protein resistance Ceefourin1 MRP4 HEK293 D-luciferin ABC ABCG2 P-gp multidrug MRP1 Inhibitor neuroblastoma Ceefourin-1 ABCC1 BCRP inhibitor

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