Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MYCMI-6 (NSC-354961) is a potent and selective inhibitor of endogenous MYC:MAX protein interactions,reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 119.00 | |
5 mg | In stock | $ 297.00 | |
10 mg | In stock | $ 478.00 | |
25 mg | In stock | $ 997.00 | |
50 mg | In stock | $ 1,580.00 | |
100 mg | In stock | $ 2,130.00 | |
200 mg | In stock | $ 2,870.00 | |
500 mg | In stock | $ 4,270.00 |
Description | MYCMI-6 (NSC-354961) is a potent and selective inhibitor of endogenous MYC:MAX protein interactions,reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects. |
In vitro | MYCMI-6 in a cell-based protein interaction screen for small inhibitory molecules.?MYCMI-6 exhibits strong selective inhibition of MYC:MAX interaction in cells and in vitro at single-digit micromolar concentrations, as validated by split Gaussia luciferase, in situ proximity ligation, microscale thermophoresis and surface plasmon resonance (SPR) assays.?Further, MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a KD of 1.6 0.5 μM as demonstrated by SPR.?MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner with IC50 concentrations as low as 0.5 μM, while sparing normal cells.?The response to MYCMI-6 correlates with MYC expression based on data from 60 human tumor cell lines and is abrogated by MYC depletion.?Further, it inhibits MYC:MAX interaction, reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects. |
In vivo | MYCMI-6 ?induces massive apoptosis and reduces tumor cell proliferation, tumor microvasculature density and MYC:MAX interaction in a MYC-dependent xenograft tumor model[1]. |
Synonyms | NSC354961 |
Molecular Weight | 373.41 |
Formula | C20H19N7O |
CAS No. | 681282-09-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.3 mg/mL (6.16 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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