neurite — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6S1740	Nardosinone		Others
	1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t...		Others
TQ0218	Deoxyandrographolide	14-deoxyandrographolide	IL Receptor , TNF
	Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6.		IL Receptor , TNF
T8869	B355252		Others
	B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.		Others
T11861	LM11A-31 dihydrochloride		Others
	LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagoni...		Others
T2306	Brexpiprazole	OPC-34712	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
	Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.		Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
T2S0843	Negletein	7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor , TNF , NOS , Interleukin
	1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n...		IL Receptor , TNF , NOS , Interleukin
T8690	Brexpiprazole HCl	OPC 34712 dihydrochloride	Others
	Brexpiprazole HCl (OPC 34712 dihydrochloride) is a new antipsychotic drug.		Others
T32658L	Leteprinim	AIT082 acid,AIT 082 acid,AIT-082 acid	Others
	Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes.		Others
T3S1589	Notoginsenoside Fa		Others
	1. Notoginsenosides Fa and R4 show significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells.		Others
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
T16518	PH-002		Others
	PH-002, an inhibitor targeting the intramolecular domain interaction of apolipoprotein (apo) E4 in neuronal cells, additionally enhances mitochondrial motility and promotes neurite outgrowth, thereby countering related i...		Others
T2S0531	Pinoresinol dimethyl ether	(+)-Eudesmin	Others , PKC
	Pinoresinol dimethyl ether, a non-phenolic furan lignan isolated from the bark of Magnolia kobus, exhibits neuroactivity. It stimulates upstream MAPK, PKC, and PKA pathways, inducing neurite outgrowth in PC12 cells.		Others , PKC
TN1038	Galgravin		Apoptosis
	Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protec...		Apoptosis
T10624	BT-13		c-RET
	BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.		c-RET
TN1544	D-Menthol	Menthol,(+)-MENTHOL	Calcium Channel , 5-HT Receptor , AChR
	D-Menthol ((+)-MENTHOL) is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neurite, suggests that menthol...		Calcium Channel , 5-HT Receptor , AChR
T9504	MAP4343		Microtubule Associated
	Map4343 is a 3-methyl ether derivative of pregnenolone. Map4343 binds to microtubule associated protein 2 (MAP2) in vitro and stimulates tubulin polymerization, resulting in enhanced neurite extension and protection of n...		Microtubule Associated
T15602	ITX3		Others , Rho
	ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in P...		Others , Rho
T2787	Picroside I	6'-Cinnamoylcatalpol	MMP , STAT
	Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug ...		MMP , STAT
T4431	Olodanrigan	PD-126055,EMA401	RAAS
	Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA...		RAAS
T32541	Lalioside
	Lalioside is a potent accelerator of neurite outgrowth.