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Olodanrigan

Catalog No. T4431 CAS 1316755-16-4

Synonyms: PD-126055, EMA401

Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA401 blocks p38, p42/p44 mitogen-activated protein kinase (MAPK) activation, neurite outgrowth in adult rat DRG neurons, and sensitization of adult rat and human DRG neurons induced by AngII. It inhibits capsaicin responses in cultured hDRG neurons.

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Olodanrigan, CAS 1316755-16-4

Pack Size	Availability	Price/USD
2 mg	In stock	$ 42.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 360.00
100 mg	In stock	$ 535.00
1 mL * 10 mM (in DMSO)	In stock	$ 76.00

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Purity: 94.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	PD-126055, EMA401
Molecular Weight	507.58
Formula	C32H29NO5
CAS No.	1316755-16-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (98.51 mM)

References and Literature

1. Rice A S C, Dworkin R H, McCarthy T D, et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 Clinicalal trial[J]. The Lancet, 2014, 383(9929): 1637-1647. 2. Anand U, Yiangou Y, Sinisi M, et al. Mechanisms underlying Clinicalal efficacy of Angiotensin II type 2 receptor (AT 2 R) antagonist EMA401 in neuropathic pain: Clinicalal tissue and in vitro studies[J]. Molecular pain, 2015, 11(1): 38.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Highly Selective Inhibitor Library Orally Active Compound Library Anti-Diabetic Compound Library Angiogenesis related Compound Library Anti-Metabolism Disease Compound Library Endocrinology-Hormone Compound Library Anti-Hypertension Compound Library Bioactive Compounds Library Max

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Angiotensin II (3-8), human TFA DX600 TFA L162441 Angiotensin II human acetate Fimasartan Buloxibutid Zofenopril calcium Eprosartan

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Keywords

Olodanrigan 1316755-16-4 Endocrinology/Hormones RAAS inhibit EMA-401 PD-126055 PD126055 EMA401 Angiotensin Receptor Inhibitor EMA 401 PD 126055 inhibitor

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