Powder: -20°C for 3 years
In solvent: -80°C for 2 years
BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.
Description | BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro. |
In vitro | BT-13 stimulates phosphorylation of RET and RET-dependent intracellular signaling but activated neither BDNF receptor TrkB nor NGF receptor TrkA nor intracellular signaling in the absence of RET. |
In vivo | In rats with surgery-induced neuropathy, BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons. |
Molecular Weight | 517.54 |
Formula | C23H27F4N3O4S |
CAS No. | 924537-98-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 25 mg/mL (48.31 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BT-13 924537-98-4 蛋白酪氨酸激酶 凋亡 c-RET RET Inhibitor inhibit BT13 BT 13 inhibitor