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Picroside I

Catalog No. T2787   CAS 27409-30-9
Synonyms: 6'-Cinnamoylcatalpol

Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug candidates for cancer therapy by suppressing Collagenases and Gelatinases. Picroside I can enhance basic fibroblast growth factor(bFGF)-, staurosporine- or dbc-mitogen-activated protein (MAP)-induced neurite outgrowth from PC12D cells.

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Picroside I Chemical Structure
Picroside I, CAS 27409-30-9
Pack Size Availability Price/USD Quantity
20 mg In stock $ 50.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.43%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug candidates for cancer therapy by suppressing Collagenases and Gelatinases. Picroside I can enhance basic fibroblast growth factor(bFGF)-, staurosporine- or dbc-mitogen-activated protein (MAP)-induced neurite outgrowth from PC12D cells.
In vitro Picroside I and Picroside II caused a concentration-dependent (> 0.1 microM) enhancement of basic fibroblast growth factor (bFGF, 2 ng/ml)-, staurosporine (10 nM)- and dibutyryl cyclic AMP (dbcAMP, 0.3 mM)-induced neurite outgrowth from PC12D cells. Furthermore, picrosides-induced enhancements of the bFGF-action were markedly inhibited by GF109203X (0.1 microM), a protein kinase C inhibitor. The expression of phosphorylated MAP kinase was markedly increased by bFGF (2 ng/ml) and dbcAMP (0.3 mM), whereas that was not enhanced by staurosporine (10 nM). Picrosides had no effect on the phosphorylation of MAP kinase induced by bFGF or dbcAMP and also unaffected it in the presence of staurosporine. These results suggest that Picroside I and Picroside II enhance bFGF-, staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying a down-stream step of MAP kinase in the intracellular MAP kinase-dependent signaling pathway.
Source
Synonyms 6'-Cinnamoylcatalpol
Molecular Weight 492.47
Formula C24H28O11
CAS No. 27409-30-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL

Ethanol: 10 mg/mL

DMSO: 55 mg/mL (111.68 mM)

TargetMolReferences and Literature

1. Chander R, et al. Picroliv, picroside-I and kutkoside from Picrorhiza kurrooa are scavengers of superoxide anions. Biochem Pharmacol. 1992 Jul 7;44(1):180-3.

Related compound libraries

This product is contained In the following compound libraries:
Ferroptosis Compound Library Traditional Chinese Medicine Monomer Library Anti-Tumor Natural Product Library RO5 Drug-like Natural Product Library Anti-Pancreatic Cancer Compound Library Antiparasitic Natural Product Library Anti-Aging Compound Library Covalent Natural Product Library Bioactive Compound Library Preclinical Compound Library

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Keywords

Picroside I 27409-30-9 JAK/STAT signaling Proteases/Proteasome Stem Cells STAT MMP Inhibitor 6'-Cinnamoylcatalpol inhibit inhibitor

 

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