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LM11A-31 dihydrochloride

Catalog No. T11861 CAS 1243259-19-9

LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist.

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LM11A-31 dihydrochloride Chemical Structure

LM11A-31 dihydrochloride, CAS 1243259-19-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 63.00
25 mg	In stock	$ 137.00
50 mg	In stock	$ 202.00
100 mg	In stock	$ 369.00
200 mg	In stock	$ 553.00
500 mg	In stock	$ 892.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist.
In vivo	LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice[2].?LM11A-31 (oral gavage;?50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity[1].

Molecular Weight	316.27
Formula	C12H27Cl2N3O2
CAS No.	1243259-19-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 125 mg/mL (395.23 mM), Sonification is recommended.

References and Literature

1. Elshaer SL, et al. Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinalvascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62(8):1488-1500. 2. Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Orally Active Compound Library NO PAINS Compound Library CNS-Penetrant Compound Library Clinical Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

LM11A-31 dihydrochloride 1243259-19-9 Others cholinergic proNGF Inhibitor inhibit LM11A-31 growth dystrophy disease p75 Neurotensin Receptor LM-11A-31 dihydrochloride nerve neurite receptor barrier neurotrophin factor Ligand LM11A 31 dihydrochloride blood-brain LM11A31 dihydrochloride Alzheimer's p75NTR LM11A-31 Dihydrochloride inhibitor

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