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Leteprinim

Catalog No. T32658L CAS 138117-50-7

Synonyms: AIT082 acid, AIT 082 acid, AIT-082 acid

Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes.

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Leteprinim, CAS 138117-50-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 148.00
5 mg	In stock	$ 336.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,130.00
100 mg	In stock	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes.
In vitro	Leteprinim stimulates the outgrowth of neurites from PC12 cells and neurons, stimulates the synthesis and/or release of neurotrophic factors from astrocytes, enhances nerve fibre regeneration in vivo, and enhances memory in animals and humans. Leteprinim also protects against glutamate neurotoxicity in vitro and in vivo, which has led to successful tests of Leteprinim in animal models of acute central nervous system injury[3].
In vivo	Leteprinim (60 mg/kg/day; i.p., for 7 days, starting from 20 min before the kainate injection) did not modify the seizures caused by kainate but, like diazepam, it decreased kainate-induced mortality, the reduction of GAD activity, and the loss of hippocampal neurons in rats[2].

Synonyms	AIT082 acid, AIT 082 acid, AIT-082 acid
Molecular Weight	327.29
Formula	C15H13N5O4
CAS No.	138117-50-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12.5 mg/mL (38.19 mM)

References and Literature

1. Morrone CD, et al. Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease. PLoS One. 2016 Oct 21;11(10):e0165393. 2. Di Iorio P, et al. AIT-082 is neuroprotective against kainate-induced neuronal injury in rats. Exp Neurol. 2001 Jun;169(2):392-9. 3. Rathbone MP, et al. AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury. Expert Opin Investig Drugs. 1999 Aug;8(8):1255-62. 4. Johnston TH, Brotchie JM. Drugs in development for Parkinson's disease. Curr Opin Investig Drugs. 2004 Jul;5(7):720-6. Review.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compounds Library Max ReFRAME Related Library Bioactive Compound Library Human Metabolite Library Clinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Leteprinim 138117-50-7 Others AIT082 acid AIT 082 acid AIT-082 acid inhibitor inhibit

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