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Galgravin

Catalog No. TN1038   CAS 528-63-2

Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protect against neuronal death from 1-methyl-4-phenylpyridinium ion (MPP+)-induced toxicity in cultured rat hippocampal neurons.

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Galgravin Chemical Structure
Galgravin, CAS 528-63-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 217.00
5 mg In stock $ 540.00
10 mg In stock $ 779.00
25 mg In stock $ 1,180.00
50 mg In stock $ 1,620.00
100 mg In stock $ 2,180.00
1 mL * 10 mM (in DMSO) In stock $ 550.00
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Purity: 99.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protect against neuronal death from 1-methyl-4-phenylpyridinium ion (MPP+)-induced toxicity in cultured rat hippocampal neurons.
In vitro This approach resulted in the isolation and characterization of eight tetrahydrofuran neolignans: calopeptin (1), machilin-G (2), machilin-I (3), aristolignin (4), nectandrin A (5), veraguensin (6), ganschisandrin (7), and Galgravin (8). Different assays were conducted to evaluate their cytotoxic activities and to determine the possible mechanism(s) related to the activity displayed against human leukemia cells. The most active compounds 4, 5 and 8 gave IC50 values of 14.2 ± 0.7, 16.9 ± 0.8 and 16.5 ± 0.8 μg/mL, respectively, against human leukemia (HL-60) tumor cells. Moreover, these compounds induced specific apoptotic hallmarks, such as plasma membrane bleb formation, nuclear DNA condensation, specific chromatin fragmentation, phosphatidyl-serine exposure on the external leaflet of the plasma membrane, cleavage of PARP as well as mitochondrial damage, which as a whole could be related to the intrinsic apoptotic pathway.
Source
Molecular Weight 372.45
Formula C22H28O5
CAS No. 528-63-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (24.16 mM)

TargetMolReferences and Literature

1. Neolignans from Nectandra megapotamica (Lauraceae) Display in vitro Cytotoxic Activity and Induce Apoptosis in Leukemia Cells.Molecules. 2015 Jul 15;20(7):12757-68.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Tumor Natural Product Library Traditional Chinese Medicine Monomer Library Traditional Mongolian Medicine Compound Library Selected Plant-Sourced Compound Library Immunology/Inflammation Compound Library RO5 Drug-like Natural Product Library Bioactive Compound Library Natural Product Library for HTS Natural Product Library Chinese Pharmacopoeia Natural Product Library

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Keywords

Galgravin 528-63-2 Apoptosis inhibit Inhibitor inhibitor

 

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