mice — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5661	Methyl isoeugenol		Others
	methyl isoeugenol (MIE) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food addit...		Others
T38514	PMEDAP		Others , HIV Protease
	PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP also has anti-murine cytomega...		Others , HIV Protease
T40187	GNF2133		DYRK
	GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.		DYRK
T36692	Fanotaprim		DHFR
	Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o...		DHFR
T5477	ELQ-300		Parasite
	ELQ-300 is bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1)		Parasite
T8574	SPHINX		Others
	SPHINX is a new generation inhibitor of SPRK1		Others
T41277	PACMA 31		Others
	PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.		Others
T29126	VU0360172	VU-0360172,VU 0360172	GluR
	VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).		GluR
T7149	S29434		NADPH , Autophagy
	S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).		NADPH , Autophagy
T7156	NIBR189		EBI2/GPR183
	NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors, respectively)		EBI2/GPR183
T9266	Fatostatin		Lipid , Fatty Acid Synthase
	Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.		Lipid , Fatty Acid Synthase
T5345	V-9302		Others
	V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).		Others
T9521	CHR-6494 TFA		Others
	CHR-6494 TFA is a potent haspin inhibitor, with an IC50 of 2 nM. It inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be use...		Others
T8222	Selpercatinib	LOXO-292	c-RET
	Selpercatinib (LOXO-292) is a tyrosine kinase inhibitor with antineoplastic properties(IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively)		c-RET
T2014	CCG-1423	CCG1423	LRRK2 , Rho , Ras
	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.		LRRK2 , Rho , Ras
T8954	ML179	ML-179	Others
	ML179 is a potent and selective inverse agonist of liver receptor homolog-1 (LRH1, NR5A2) with IC50 of 320 nM.		Others
T12079	ML604440		Proteasome
	ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.		Proteasome
T1115	Doxylamine succinate	Decapryn	Histamine Receptor
	Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ...		Histamine Receptor
T9072	Tuxobertinib	BDTX-189	EGFR , HER , BTK , RIP kinase
	Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activ...		EGFR , HER , BTK , RIP kinase
T15249	Estrogen receptor modulator 1		Estrogen Receptor/ERR
	Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.4...		Estrogen Receptor/ERR