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Tuxobertinib

Catalog No. T9072 CAS 2414572-47-5

Synonyms: BDTX-189

Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activity.

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Tuxobertinib, CAS 2414572-47-5

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 372.00
100 mg	In stock	$ 553.00
200 mg	In stock	$ 792.00
1 mL * 10 mM (in DMSO)	In stock	$ 68.00

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Purity: 98.86%

Biological Description

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Storage & Solubility Information

Description	Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activity.
Targets&IC50	EGFR:0.2 nM(KD), BLK:13 nM(KD), RIPK2:1.2 nM(KD), HER2:0.76 nM(KD)
In vivo	BDTX-189 (0-100 mg/kg;?p.o.;?daily for 15 dyas) shows dose-dependent tumor growth inhibition and regression in in athymic nude mice bearing HER2 S310F Ba/F3 allograft tumors.?BDTX-189 (1-50 mg/kg.p.o.;?daily for 15 days) shows dose-dependent tumor growth inhibition and regression in athymic nude mice bearing CUTO-14 PDX tumors that express the EGFR mutation EGFR ASV

Synonyms	BDTX-189
Molecular Weight	561.03
Formula	C29H29ClN6O4
CAS No.	2414572-47-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 41.67 mg/mL (74.27 mM), Sonication is recommended.

References and Literature

1. Elizabeth Buck, et al. BDTX-189, a Potent and Selective Inhibitor of Allosteric EGFR and HER2 Oncogenic Mutations.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library Anti-Ovarian Cancer Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tuxobertinib 2414572-47-5 Angiogenesis Apoptosis JAK/STAT signaling NF-Κb Tyrosine Kinase/Adaptors HER EGFR BTK RIP kinase inhibit BDTX189 ErbB-1 mutants Epidermal growth factor receptor BDTX-189 nude allosteric Ba/F3 BDTX 189 HER1 oncogene athymic oral mice insertion Inhibitor inhibitor

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