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Fanotaprim
🥰Excellent
Catalog No. T36692Cas No. 2120282-75-7
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor, suppressing the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM, a hDHFR IC50 of 308 ± 71 nM, and a hDHFR to TgDHFR selectivity ratio of 196.
Fanotaprim
🥰Excellent
Purity: 97.37%
Catalog No. T36692Cas No. 2120282-75-7
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor, suppressing the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM, a hDHFR IC50 of 308 ± 71 nM, and a hDHFR to TgDHFR selectivity ratio of 196.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 2 mg | $68 | In Stock | |
| 5 mg | $118 | In Stock | |
| 10 mg | $188 | In Stock | |
| 25 mg | $353 | In Stock | |
| 50 mg | $492 | In Stock | |
| 100 mg | $696 | In Stock | |
| 200 mg | $938 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $130 | In Stock |
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Purity:97.37%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor, suppressing the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM, a hDHFR IC50 of 308 ± 71 nM, and a hDHFR to TgDHFR selectivity ratio of 196. |
| Targets&IC50 | TgDHFR:1.57 ± 0.11 nM(Toxoplasma gondii), DHFR (human):308 ± 71 nM(human) |
| In vitro | Fanotaprim exhibits parasiticidal and antiproliferative effects with EC50s of 13 and 7300 nM against the type I RH strain of T. gondii and MCF-7 cells, respectively[1]. It also inhibits the growth of T. gondii strains in vitro with EC50s ranging from 7.6 to 29.8 nM (GT1, ME49, CTG, RUB, and VAND)[1]. |
| In vivo | Fanotaprim (1-10 mg/kg; p.o.; daily; beginning on day 1 through day 7) is highly effective in controlling acute infection by highly virulent strains of T. gondii in the murine model[1]. In mice, Fanotaprim (1 mg/kg; i.v.) shows CL, Vd, and t1/2 values of 10.6 mL/min/kg, 1.14 L/kg, and 3.9 hours, respectively[1]. When administered orally at 0.83 mg/kg, Fanotaprim exhibits F, Cmax, Tmax, and AUC0-last values of 47.3%, 178 ng/mL, 0.05 hours, and 750 ng h/mL, respectively[1]. |
| Molecular Weight | 378.43 |
| Formula | C19H22N8O |
| Cas No. | 2120282-75-7 |
| Smiles | COc1ncc(cn1)-c1cccc(c1)N1CCN(CC1)c1cnc(N)nc1N |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (66.06 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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