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Fanotaprim

Catalog No. T36692   CAS 2120282-75-7

Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio of 196.

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Fanotaprim Chemical Structure
Fanotaprim, CAS 2120282-75-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 80.00
5 mg In stock $ 197.00
10 mg In stock $ 313.00
25 mg In stock $ 588.00
50 mg In stock $ 838.00
100 mg In stock $ 1,160.00
1 mL * 10 mM (in DMSO) In stock $ 217.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio of 196.
Targets&IC50 hDHFR:308 ± 71 nM(human), TgDHFR:1.57 ± 0.11 nM(Toxoplasma gondii)
In vitro Fanotaprim shows parasiticidal and antiproliferative effects with EC50s of 13 and 7300 nM against the type I RH strain of T. gondii and MCF-7 cells, respectively[1].Fanotaprim shows ability to inhibit the growth of T. gondii strains in vitro with EC50s ranging 7.6~ 29.8 nM (GT1, ME49, CTG, RUB and VAND)[1].
In vivo Fanotaprim (1-10 mg/kg; p.o.; daily; beginning on day 1 through day 7) shows highly effective in control of acute infection by highly virulent strains of T. gondii in the murine model[1].Fanotaprim (1mg/kg; i.v; mouse) shows CL, Vd, and t1/2 values of 10.6 mL/min/kg, 1.14 L/kg, and 3.9 hours, respectively[1].Fanotaprim (0.83 mg/kg; p.o; mouse) shows F, Cmax, Tmax, and AUC0-last of 47.3%, 178 ng/mL, 0.05 hours and 750 ng h/mL, respectively[1].
Molecular Weight 378.43
Formula C19H22N8O
CAS No. 2120282-75-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (66.06 mM)

TargetMolReferences and Literature

1. Hopper AT, et al. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J Med Chem. 2019;62(3):1562-1576.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Parasitic Compound Library Metabolism Compound Library Bioactive Compound Library Inhibitor Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library Anti-Cancer Compound Library

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Keywords

Fanotaprim 2120282-75-7 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism DHFR CD-1 Inhibitor mice VYR 006 VYR-006 inhibit Antifolate dhydrofolate reductase survival toxoplasmosis VYR006 inhibitor

 

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