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Fanotaprim

Catalog No. T36692 CAS 2120282-75-7

Fanotaprim is a dihydrofolate <a href="/target/Reductase" style="display: inline; color: #c13a36">Reductase</a> (<a href="/target/DHFR" style="display: inline; color: #c13a36">DHFR</a>) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a Tg<a href="/target/DHFR" style="display: inline; color: #c13a36">DHFR</a> IC50 of 1.57 ± 0.11 nM and a h<a href="/target/DHFR" style="display: inline; color: #c13a36">DHFR</a> IC50 of 308 ± 71 nM and a h<a href="/target/DHFR" style="display: inline; color: #c13a36">DHFR</a> to Tg<a href="/target/DHFR" style="display: inline; color: #c13a36">DHFR</a> selectivity ratio of 196.

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Fanotaprim, CAS 2120282-75-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 108.00
5 mg	In stock	$ 221.00
10 mg	In stock	$ 347.00
25 mg	In stock	$ 651.00
50 mg	In stock	$ 997.00
100 mg	In stock	$ 1,667.00
1 mL * 10 mM (in DMSO)	In stock	$ 236.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio of 196.
Targets&IC50	hDHFR:308 ± 71 nM(human), TgDHFR:1.57 ± 0.11 nM(Toxoplasma gondii)
In vitro	Fanotaprim shows parasiticidal and antiproliferative effects with EC50s of 13 and 7300 nM against the type I RH strain of T. gondii and MCF-7 cells, respectively[1].Fanotaprim shows ability to inhibit the growth of T. gondii strains in vitro with EC50s ranging 7.6~ 29.8 nM (GT1, ME49, CTG, RUB and VAND)[1].
In vivo	Fanotaprim (1-10 mg/kg; p.o.; daily; beginning on day 1 through day 7) shows highly effective in control of acute infection by highly virulent strains of T. gondii in the murine model[1].Fanotaprim (1mg/kg; i.v; mouse) shows CL, Vd, and t1/2 values of 10.6 mL/min/kg, 1.14 L/kg, and 3.9 hours, respectively[1].Fanotaprim (0.83 mg/kg; p.o; mouse) shows F, Cmax, Tmax, and AUC0-last of 47.3%, 178 ng/mL, 0.05 hours and 750 ng h/mL, respectively[1].

Molecular Weight	378.44
Formula	C19H22N8O
CAS No.	2120282-75-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 25 mg/mL (66.06 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hopper AT, et al. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J Med Chem. 2019;62(3):1562-1576.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Bioactive Compounds Library Max Anti-Parasitic Compound Library Metabolism Compound Library Bioactive Compound Library Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Fanotaprim 2120282-75-7 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism DHFR CD-1 Inhibitor mice VYR 006 VYR-006 inhibit Antifolate dhydrofolate reductase survival toxoplasmosis VYR006 inhibitor

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