Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Fanotaprim is a dihydrofolate <a href="/target/Reductase" style="display: inline; color: #c13a36">Reductase</a> (<a href="/target/DHFR" style="display: inline; color: #c13a36">DHFR</a>) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a Tg<a href="/target/DHFR" style="display: inline; color: #c13a36">DHFR</a> IC50 of 1.57 ± 0.11 nM and a h<a href="/target/DHFR" style="display: inline; color: #c13a36">DHFR</a> IC50 of 308 ± 71 nM and a h<a href="/target/DHFR" style="display: inline; color: #c13a36">DHFR</a> to Tg<a href="/target/DHFR" style="display: inline; color: #c13a36">DHFR</a> selectivity ratio of 196.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 108.00 | |
5 mg | In stock | $ 221.00 | |
10 mg | In stock | $ 347.00 | |
25 mg | In stock | $ 651.00 | |
50 mg | In stock | $ 997.00 | |
100 mg | In stock | $ 1,667.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 236.00 |
Description | Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio of 196. |
Targets&IC50 | hDHFR:308 ± 71 nM(human), TgDHFR:1.57 ± 0.11 nM(Toxoplasma gondii) |
In vitro | Fanotaprim shows parasiticidal and antiproliferative effects with EC50s of 13 and 7300 nM against the type I RH strain of T. gondii and MCF-7 cells, respectively[1].Fanotaprim shows ability to inhibit the growth of T. gondii strains in vitro with EC50s ranging 7.6~ 29.8 nM (GT1, ME49, CTG, RUB and VAND)[1]. |
In vivo | Fanotaprim (1-10 mg/kg; p.o.; daily; beginning on day 1 through day 7) shows highly effective in control of acute infection by highly virulent strains of T. gondii in the murine model[1].Fanotaprim (1mg/kg; i.v; mouse) shows CL, Vd, and t1/2 values of 10.6 mL/min/kg, 1.14 L/kg, and 3.9 hours, respectively[1].Fanotaprim (0.83 mg/kg; p.o; mouse) shows F, Cmax, Tmax, and AUC0-last of 47.3%, 178 ng/mL, 0.05 hours and 750 ng h/mL, respectively[1]. |
Molecular Weight | 378.44 |
Formula | C19H22N8O |
CAS No. | 2120282-75-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 25 mg/mL (66.06 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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