keratinocytes — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6S0923	Hypericin	Hypericine,Cyclosan	Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC
	1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL...
TN2286	Tsugaric acid A		NO Synthase
	Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates t...		NO Synthase
TN1675	Gardenin B		Apoptosis , ROS , Caspase , NO Synthase
	Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .		Apoptosis , ROS , Caspase , NO Synthase
T67858	STIMA-1	2-Vinylquinazolin-4-ol,p53 Activator VII	Others
	STIMA-1 (2-Vinylquinazolin-4-ol), an active compound, can restore the activity of p63. STIMA-1 can stimulate the proliferation and differentiation of keratinocytes.		Others
T15410	GNF351		Aryl Hydrocarbon Receptor
	GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes wit...		Aryl Hydrocarbon Receptor
T5S1286	(+)-Columbianetin	(S)-Columbianetin,Columbianetin	Antifungal
	(+)-Columbianetin ((S)-Columbianetin) is a new phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage, it also has antifungal activity. (+)-Columbianetin has anti-inflammatory effect...		Antifungal
T3717	Hinokitiol	4-Isopropyltropolone,β-thujaplicin	DNA Methyltransferase , Virus Protease , Estrogen/progestogen Receptor , Nrf2
	Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent...
TP1293	Jagged-1 (188-204) TFA(219127-21-6 free base)	Jagged-1 (188-204) TFA	Gamma-secretase
	Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing sub...		Gamma-secretase
T76924	Efalizumab	Hu1124,HU 1124	Integrin
	Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinoc...		Integrin
T77677	12R-LOX-IN-2		Lipoxygenase
	12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein...		Lipoxygenase
T6S1572	Sauchinone		ERK , p38 MAPK , NF-κB
	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative...		ERK , p38 MAPK , NF-κB
T24025	Eckol
	Eckol inhibits ultraviolet B-induced cell damage by a decrease in oxidative stress in human keratinocytes.
T24094	Glycerophosphoinositol lysine	Distinctive gpi lysine,Gpi lysine
	Glycerophosphoinositol lysine has an anti-dandruff, anti-inflammatory, anti-aging activity. It significantly suppresses UVB - induced PGE secretion in NHEK keratinocytes.
T68470	ASB-16165
	ASB-16165 is a phosphodiesterase 7A inhibitor that impairs proliferation of keratinocytes in vitro and in vivo. Inhibitors of PDE7A including ASB16165 might be useful for the treatment of psoriasis.
T31126	CX-659S	CX659S,UNII-YG2F04AVMQ,CX 659S
	CX-659S is a novel diaminuracil derivative that indirectly inhibits Langerhans cell function by blocking the MEK1/2 -- ERK1/2 pathway in keratinocytes. CX-659S can inhibit the contact hypersensitivity induced by haptens ...
TN1235	3,4,5-Tricaffeoylquinic acid		TNF , Akt , HIV Protease
	3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and N...		TNF , Akt , HIV Protease
T13670L	(Z)-Ligustilide	cis-Ligustilide,Ligustilide A	Antibacterial
	(Z)-Ligustilide (Ligustilide A) , an active ingredient isolated from the medicinal plants Angelica acutiloba and Cnidium officinale, inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via...		Antibacterial
T80280	TLN-58
	TLN-58, an antimicrobial peptide, exhibits antibacterial activity against S. aureus, S. epidermidis, and group A Streptococcus. It also promotes the upregulation of inflammatory cytokine mRNAs in normal human keratinocyt...
T36004	1-O-Hexadecyl-sn-glycerol	1-O-Hexadecyl-sn-glycerol,(S)-(+)-Chimyl Alcohol,α-Chimyl Alcohol
	1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether. It reduces UVB-induced cell death and production of reactive oxygen species (ROS) and prostaglandin E2 in normal human epidermal keratinocytes (NHEKs). 1-O-H...
TP1540	Jagged-1 （188-204）	Jagged-1 188-204	Gamma-secretase
	Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolay...		Gamma-secretase