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Gardenin B

Catalog No. TN1675   CAS 2798-20-1

Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .

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Gardenin B Chemical Structure
Gardenin B, CAS 2798-20-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 68.00
5 mg In stock $ 160.00
10 mg In stock $ 235.00
25 mg In stock $ 395.00
50 mg In stock $ 587.00
100 mg In stock $ 839.00
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Purity: 99.74%
Purity: 98.71%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
In vitro Here we investigated the antiproliferative activity of the flavonoids isolated from Baccharis scandens against human leukemia cell lines and found that the methoxyflavonoid Gardenin B was the most cytotoxic compound against HL-60 and U-937 cells, showing IC50 values between 1.6 and 3.0 μM, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. These effects on viability were accompanied by the concentration- and time-dependent appearance of apoptosis as evidenced by DNA fragmentation, formation of apoptotic bodies and a sub-G1 ratio increase. Comparative studies with the best-studied bioflavonoid quercetin indicate that Gardenin B is a more cytotoxic and more apoptotic inducer than quercetin. Cell death induced by Gardenin B was associated with: (i) a significant induction of caspase-2, -3, -8 and -9 activities; (ii) cleavage of the initiator caspases (caspase-2, -8 and -9), of the executioner caspase-3, and of poly(ADP-ribose) polymerase; and (iii) a concentration-dependent reactive oxygen species generation[1]
Source
Molecular Weight 358.34
Formula C19H18O7
CAS No. 2798-20-1

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.58 mg/mL (10 mM)

TargetMolReferences and Literature

1. Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species.Chem Biol Interact. 2016 Aug 25;256:220-7.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Natural Product Library for HTS Anti-Inflammatory Traditional Chinese Medicine Compound Library Antioxidant Compound Library Bioactive Compounds Library Max Hematonosis Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Fibrosis Compound Library Cuproptosis Compound Library

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Keywords

Gardenin B 2798-20-1 Apoptosis Immunology/Inflammation Proteases/Proteasome ROS NO Synthase Caspase inhibit Inhibitor inhibitor

 

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