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GNF351

Catalog No. T15410 CAS 1227634-69-6

GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).

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GNF351, CAS 1227634-69-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 37.00
5 mg	In stock	$ 86.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 547.00
100 mg	In stock	$ 736.00
200 mg	In stock	$ 995.00
1 mL * 10 mM (in DMSO)	In stock	$ 107.00

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Purity: 99.04%

Biological Description

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Description	GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).
Targets&IC50	AhR:62 nM (IC50)
In vitro	After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.

Molecular Weight	411.5
Formula	C24H25N7
CAS No.	1227634-69-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 124 mg/mL(301.34 mM)

References and Literature

1. van den Bogaard EH,et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Transcription Factor-Targeted Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max

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Keywords

GNF351 1227634-69-6 Immunology/Inflammation Aryl Hydrocarbon Receptor Inhibitor AhR GNF 351 GNF-351 inhibit inhibitor

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