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Search Results for " hypertension "

20

Compounds

Cat No. Product Name Synonyms Targets
T3055 Liensinine Perchlorate Apoptosis , Others
Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
T8899 Metipranolol Adrenergic Receptor
Metipranolol (Betamann) is a type of β- Adrenergic receptors( β- A potent antagonist of adrenergic receptor on guinea pig atria β 1- Adrenergic receptors and rat uterus β The 2-adrenergic receptor exhibited the beta bloc...
TN1416 Ayanin IL Receptor , P450 , PARP , PDE
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) is 2.2microM for inhibiting interleukin (IL)-4 productio...
T13865 Resorcinolnaphthalein RAAS
Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).
T12268 NTP42 Prostaglandin Receptor , PPAR
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
T0114 Trichlormethiazide Naqua,Metahydrin,Trichlormetazid ATPase , Carbonic Anhydrase
Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and ...
T11339 Furegrelate sodium U-63557A PPAR
Furegrelate sodium (U-63557A) is a selective thromboxane synthase inhibitor with oral activity. Furegrelate sodium(U-63557A) inhibits thromboxane A2 (TXA2) synthase in human platelet microsomes with an IC50 of 15 nM.
T1385 Amlodipine UK-48340 Calcium Channel
Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.
T1484 Perindoprilat Perindoprilate RAAS , MRP , AChR
Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor.
T8372 VU0134992 VU 0134992 Potassium Channel
VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM
T4316 ML365 Potassium Channel
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).
T8900 Seralutinib GB002 PDGFR
Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.
T14315 AR-9281 APAU Epoxide Hydrolase
AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes
T6595 Moexipril hydrochloride Moexipril HCl,RS-10085,SPM 925,CI-925 Apoptosis , RAAS
Moexipril hydrochloride (Moexipril HCl) is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of hypertension and congestive heart failure.
T0231 Amlodipine Besylate Amlodipine benzenesulfonate Calcium Channel
Amlodipine Besylate(Amlodipine benzenesulfonate) is a long-lasting calcium channel blocker.
T2561 Macitentan ACT-064992 Apoptosis , Endothelin Receptor
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T1489 Fosinopril sodium SQ28555 RAAS
Fosinopril sodium is a phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.
T13316 VU0134992 hydrochloride Potassium Channel
VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 µM).
T0386L Ropivacaine LEA-103 HCl Potassium Channel , Sodium Channel
Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.
T14782 Brilaroxazine RP5063 Dopamine Receptor , 5-HT Receptor
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-...
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