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NTP42

Catalog No. T12268 CAS 2055599-51-2

NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)

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NTP42, CAS 2055599-51-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 57.00
2 mg	In stock	$ 83.00
5 mg	In stock	$ 143.00
10 mg	In stock	$ 226.00
25 mg	In stock	$ 383.00
50 mg	In stock	$ 569.00
100 mg	In stock	$ 816.00
1 mL * 10 mM (in DMSO)	In stock	$ 162.00

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Purity: 99.09%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)

In vivo

From haemodynamic assessments, NTP42 reduced the MCT-induced PAH, including mean pulmonary arterial pressure (mPAP) and right systolic ventricular pressure (RSVP), being at least comparable to the standard-of-care drugs Sildenafil or Selexipag in bringing about these effects.?Moreover, NTP42 was superior to Sildenafil and Selexipag in significantly reducing pulmonary vascular remodelling, inflammatory mast cell infiltration and fibrosis in MCT-treated animals[1].

Molecular Weight	515.53
Formula	C25H23F2N3O5S
CAS No.	2055599-51-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (58.19 mM), Sonification is recommended.

References and Literature

1. B. Therese KINSELLA, et al. Thromboxane receptor antagonists. WO2016203314A1. 2. Eamon Mulvaney, et al. NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.

Citations

1. Hao Y, Ou Y, Zhang C, et al. Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation. Brain Research. 2022, 1795: 148073.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library GPCR Compound Library Anti-Pancreatic Cancer Compound Library Transcription Factor-Targeted Compound Library Anti-Breast Cancer Compound Library Anti-Cardiovascular Disease Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

NTP42 2055599-51-2 DNA Damage/DNA Repair GPCR/G Protein Immunology/Inflammation Metabolism Prostaglandin Receptor PPAR pulmonary Inhibitor inhibit PAH NTP-42 hypertension TXA2 thromboxane arterial NTP 42 inhibitor

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