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Amlodipine Besylate

Catalog No. T0231 CAS 111470-99-6

Synonyms: Amlodipine benzenesulfonate

Amlodipine Besylate(Amlodipine benzenesulfonate) is a long-lasting calcium channel blocker.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Amlodipine Besylate, CAS 111470-99-6

Pack Size	Availability	Price/USD
500 mg	In stock	$ 33.00
1 g	In stock	$ 50.00
5 g	In stock	$ 98.00
1 mL * 10 mM (in DMSO)	In stock	$ 37.00

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Purity: 100%

Purity: 99.07%

Purity: 99.04%

Purity: 99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Amlodipine Besylate(Amlodipine benzenesulfonate) is a long-lasting calcium channel blocker.
Targets&IC50	Ca2+ channel:1.9 nM
In vitro	Amlodipine is a safe and effective oral medication for treating systemic hypertension in cats. In swine coronary arteries with intact endothelium, Amlodipine notably reduces mean indirect systolic pressure, from 198 mmHg to 155 mmHg.
In vivo	In mice infused with angiotensin II, Amlodipine significantly reduced systolic blood pressure, LOX-1 expression, endothelial dysfunction, aortic hypertrophy, and the production of aortic O2(-) and ONOO(-), alongside a decrease in plasma levels of free 8-F(2)α-isoprostanes. In isolated pre-contracted endothelium-intact porcine coronary arteries, Amlodipine induced NO-mediated relaxation, resulting in a leftward shift of the concentration-relaxation curve toward bradykinin. Electron spin resonance spectroscopy in native endothelial cells revealed that Amlodipine increased NO production and stimulated an 8-fold rise in endothelial cyclic GMP levels. Furthermore, Amlodipine induced NO-mediated relaxation in isolated rat aortic rings, leading to downregulation of B2 receptor expression. In endothelial cells, Amlodipine time-dependently attenuated protein kinase C phosphorylation, similar to endothelial nitric oxide synthase phosphorylation, and also prevented phorbol-12-myristate-13-acetate-induced PKC activation. Amlodipine besylate reduced p85αPI3K, phosphorylated GSK-3β, phosphorylated Akt, Bcl-2, and heat shock transcription factor 1 induced H2O2 content, and inhibited Cyclooxygenase-2, cytosolic cytochrome c, cleaved caspase9, and the increase of cleaved caspase3 in neuronal cell apoptosis.

Synonyms	Amlodipine benzenesulfonate
Molecular Weight	567.05
Formula	C26H31ClN2O8S
CAS No.	111470-99-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 5.7 mg/mL (10 mM)

DMSO: 56.7 mg/mL (100 mM)

References and Literature

1. Lee YJ, et al. J Neurochem, 2011, 119(6), 1262-1270. 2. Zhou MS, et al. Am J Hypertens, 2004, 17(2), 167-171. 3. Lenasi H, et al. Cardiovasc Res, 2003, 59(4), 844-853. 4. Henik RA, et al. J Am Anim Hosp Assoc, 1997, 33(3), 226-234.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library EMA Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Calcium Channel Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Amlodipine Besylate 111470-99-6 Membrane transporter/Ion channel Metabolism Calcium Channel Inhibitor hypertension antianginal Amlodipine benzenesulfonate Amlodipine Ca channels dihydropyridine inhibit oral Ca2+ channels inhibitor

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