Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 115.00 | |
2 mg | In stock | $ 159.00 | |
5 mg | In stock | $ 235.00 | |
10 mg | In stock | $ 353.00 | |
25 mg | In stock | $ 596.00 | |
50 mg | In stock | $ 849.00 | |
100 mg | In stock | $ 1,170.00 | |
500 mg | In stock | $ 2,350.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 278.00 |
Description | VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM |
Targets&IC50 | KIR4.1:0.97 µM |
In vitro | VU0134992 inhibits Kir4.1 with an IC50 value of 0.97 μM and is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50 = 9 μM) at -120 mV.?In thallium (Tl+) flux assays, VU0134992 is greater than 30-fold selective for Kir4.1 over Kir1.1, Kir2.1, and Kir2.2;?is weakly active toward Kir2.3, Kir6.2/SUR1, and Kir7.1;?and is equally active toward Kir3.1/3.2, Kir3.1/3.4, and Kir4.2. |
In vivo | VU0134992 displayed a large free unbound fraction (fu) in rat plasma (fu = 0.213).?Consistent with the known role of Kir4.1 in renal function, oral dosing of VU0134992 led to a dose-dependent diuresis, natriuresis, and kaliuresis in rats. |
Synonyms | VU 0134992 |
Molecular Weight | 411.38 |
Formula | C20H31BrN2O2 |
CAS No. | 755002-90-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (145.85 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
VU0134992 755002-90-5 Membrane transporter/Ion channel Potassium Channel natriuresis hypertension electrophysiology whole-cell selective VU 0134992 VU-0134992 diuresis oral patch-clamp KcsA Inhibitor inhibit Kir4.1 kaliuresis inhibitor