encephalomyelitis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2315	Glatiramer Acetate		Others
	Glatiramer acetate (GA) is a synthetic amino acid copolymer that is approved for treatment of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS).		Others
T28169	NIBR-0213	NIBR 0213	LPL Receptor
	NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.		LPL Receptor
T24984	5J-4		Calcium Channel
	5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.		Calcium Channel
T15795	Luzindole	N-0774	Melatonin Receptor , MT Receptor
	Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1...		Melatonin Receptor , MT Receptor
T0994	Ketotifen fumarate	HC 20511 fumarate	PDE , Histamine Receptor
	Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.		PDE , Histamine Receptor
T12422	PF-04957325		PDE
	PF-04957325 is a potent and selective inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A and 0.3 nM for PDE8B.PF-04957325 can be used to study autoimmune encephalomyelitis.		PDE
T77555	3-Methoxycatechol	1,2-Dihydroxy-3-methoxybenzene	Antiviral
	3-Methoxycatechol is a lignin-derived renewable chemical that promotes carcinogenesis in the esophagus.1,2-Dihydroxy-3-methoxybenzen exhibits strong antiviral activity against encephalomyelitis virus (EMCV).		Antiviral
T24398	Lenaldekar	LDK	Akt , IGF-1R , S6 Kinase
	Lenaldekar (LDK) inhibits T-cell expansion and autoimmune encephalomyelitis. Lenaldekar causes dephosphorylation of members of the PI3 kinase/AKT/mTOR pathway and delays sensitive cells in late mitosis.		Akt , IGF-1R , S6 Kinase
T14924	Cenerimod	ACT-334441	S1P Receptor
	Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimm...		S1P Receptor
T19107	24, 25-Dihydroxy VD2	24,25-Dihydroxy vitamin D2	Vitamin
	24, 25-Dihydroxy VD2 (24,25-Dihydroxy vitamin D2) is a metabolite of vitamin D2, which is the isomer of vitamin D present in the body as 25-hydroxyvitamin D. PF-04957325 is used in the study of autoimmune encephalomyelit...		Vitamin
T10385	ASP-4058		S1P Receptor , LPL Receptor
	ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice.		S1P Receptor , LPL Receptor
T3426	Bacoside A		MMP , Others , TNF , Dopamine Receptor , NOS , ROS
	Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidat...		MMP , Others , TNF , Dopamine Receptor , NOS , ROS
T22398	Phenidone	1-phenyl-3-pyrazolidinone	Lipoxygenase , COX
	Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxyg...		Lipoxygenase , COX
T0511	Tolperisone hydrochloride	Muscalm,Midocalm,Tolperisone HCl	Sodium Channel
	Tolperisone hydrochloride (Muscalm), a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological diseases (damage of the encephalomyel...		Sodium Channel
T21509	CA 074		Cysteine Protease
	CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopathy and optic neuritis in experimental autoimmune encephalom...		Cysteine Protease
T3701	MCC950	CP-456773	NOD
	CP-456773 (MCC950 (CP-456773) and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and caspase 1 processing. MCC950 blocked canonical and...		NOD
T81734	Myelin Basic Protein (1-11)
	Myelin Basic Protein (1-11), an encephalitogenic epitope of MBP, facilitates the induction of experimental autoimmune encephalomyelitis (EAE) [1] [2].
T82424	Experimental allergic encephalitogenic peptide (human)
	Experimental allergic encephalitogenic peptide (human), an EAE peptide, induces encephalomyelitis in guinea pigs [1].
T30529	BMS-520
	BMS-520 is a potent, selective S1P1 agonist that has shown impressive efficacy when administered orally in a rat model of arthritis and in a mouse model of experimental autoimmune encephalomyelitis (EAE) with multiple sc...
T63206	SR12418
	SR12418 is a specific REV-ERB synthetic ligand that acts on REV-ERBα (IC50: 68 nM) and REV-ERBβ (IC50: 119 nM) and can be used to study experimental autoimmune encephalomyelitis (EAE) and colitis.