Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 119.00 | |
5 mg | In stock | $ 297.00 | |
10 mg | In stock | $ 488.00 | |
25 mg | In stock | $ 798.00 | |
50 mg | In stock | $ 1,090.00 | |
100 mg | In stock | $ 1,480.00 | |
500 mg | In stock | $ 2,930.00 |
Description | ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice. |
In vitro | ASP4058 (100 nM) significantly reduced FITC-dextran leakage through an endothelial monolayer and suppressed the migration of macrophages across the monolayer in vitro by using a Transwell system.[2] |
In vivo |
ASP4058 (0.1 and 0.3 mg/kg; p.o.; daily for day 12 to day 45) maintains the clinical score at a relatively low level and the cumulative clinical scores (18-45 dpi) among the groups treated with 0.1 and 0.3 mg/kg dosages are 6.90±2.85 and 5.60±2.21, respectively in mice. The ED50 value for ASP4058 is 0.063 mg/kg.[1] ASP4058 (0.03, 0.1, and 0.3 mg/kg; p.o., daily for 21 days) reduces the clinical score in a dose-dependent manner and the cumulative clinical score from day 0 to 21 dpi at 0.03, 0.1, and 0.3 mg/kg are 15.5±1.48, 9.50±2.17 and 1.17±1.17, respectively, while that of the vehicle-treated group is 15.5±0.619 in rats.[1] |
Molecular Weight | 442.31 |
Formula | C19H12F6N4O2 |
CAS No. | 952565-91-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (101.7 mM)
You can also refer to dose conversion for different animals. More
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ASP-4058 952565-91-2 GPCR/G Protein S1P Receptor LPL Receptor ASP4058 ASP 4058 inhibitor inhibit