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PF-04957325

Catalog No. T12422 CAS 1305115-80-3

PF-04957325 is a potent and selective inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A and 0.3 nM for PDE8B.PF-04957325 can be used to study autoimmune encephalomyelitis.

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PF-04957325, CAS 1305115-80-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 139.00
5 mg	In stock	$ 347.00
10 mg	In stock	$ 541.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,490.00
100 mg	In stock	$ 1,990.00
1 mL * 10 mM (in DMSO)	In stock	$ 341.00

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Purity: 99.02%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PF-04957325 is a potent and selective inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A and 0.3 nM for PDE8B.PF-04957325 can be used to study autoimmune encephalomyelitis.
Targets&IC50	PDE8B:0.2 nM, PDE8A:0.7 nM
In vitro	The PDE8 selective inhibitor PF-04957325 exhibits an IC50 of 0.7 nM for PDE8A and 0.2 nM for PDE8B, while its IC50 for all other PDE isoforms is greater than 1.5 μM [3]. Treatment with PF-04957325 in WT Leydig cells or MA10 cells increases steroid production, but has no effect in PDE8A(-/-)/B(-/-) double knockout cells, indicating the drug's specificity [4].

Molecular Weight	400.38
Formula	C14H15F3N8OS
CAS No.	1305115-80-3

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (200 mM), Sonication is recommended.

References and Literature

1. Vang AG, et al. Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation. Front Pharmacol. 2016 Aug 23;7:259. 2. Dong H, et al. Inhibition of breast cancer cell migration by activation of cAMP signaling. Breast Cancer Res Treat. 2015 Jul;152(1):17-28. 3. Tsai LC, et al. Regulation of adrenal steroidogenesis by the high-affinity phosphodiesterase 8 family. Horm Metab Res. 2012 Sep;44(10):790-4. 4. Shimizu-Albergine M, et al. cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis. Mol Pharmacol. 2012 Apr;81(4):556-66.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PF-04957325 1305115-80-3 Metabolism PDE PF04957325 PF 04957325 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.