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MCC950

Catalog No. T3701    CAS 210826-40-7    Synonyms: CP-456773

CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced IL-1β production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis.

Pack Size Availability Price/USD Quantity
2 mg Inquiry 50.00
5 mg Inquiry 80.00
10 mg Inquiry 140.00
25 mg Inquiry 273.00
100 mg Inquiry 968.00
1 mL * 10 mM (in DMSO) Inquiry 96.00
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Biological Activity:

Product Description:

CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced IL-1β production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis.

Receptor:

NLRP3;

Chemical Information:
Molecular Weight 404.48
Formula C20H24N2O5S
CAS Number 210826-40-7
Solubility

DMSO: ≥28 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.