Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 41.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[2]. |
In vitro | Western blot analysis showed that phenidone significantly inhibited the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with EAE[1]. |
In vivo | Lipoxygenase inhibitor phenidone markedly attenuates angiotensin II (AII) induced vascular contractility. Phenidone was also shown to inhibit the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat[2]. |
Synonyms | 1-phenyl-3-pyrazolidinone |
Molecular Weight | 162.19 |
Formula | C9H10N2O |
CAS No. | 92-43-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 99 mg/mL (610.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Phenidone 92-43-3 Immunology/Inflammation Metabolism Neuroscience Lipoxygenase COX hypertensive LOX developer pressure autoimmune 1-phenyl-3-pyrazolidinone Cyclooxygenase oral photographic blood inhibit Inhibitor inhibitor