Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimmune encephalomyelitis (EAE) and murine scleroderma.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 35.00 | |
5 mg | In stock | $ 56.00 | |
10 mg | In stock | $ 95.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 62.00 |
Description | Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimmune encephalomyelitis (EAE) and murine scleroderma. |
Targets&IC50 | S1PR4:2134 nM (EC50), S1PR1:1 nM (EC50), S1PR5:228 nM (EC50), S1PR5:36 nM (EC50) |
In vitro | Cultured fibroblasts were pretreated with a vehicle or Cenerimod (5 μmol/L), followed by incubation with TGF-β2 (10 ng/mL) for 24 hours. The results indicated that Cenerimod inhibited collagen production in fibroblasts[1]. |
In vivo | In male Wistar rats weighing 294-510 g, Cenerimod (0.1, 0.3, 1, 3, and 10 mg/kg; single oral dose) effectively and reversibly reduced blood lymphocyte counts[1]. |
Synonyms | ACT-334441 |
Molecular Weight | 453.53 |
Formula | C25H31N3O5 |
CAS No. | 1262414-04-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (176.39 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Cenerimod 1262414-04-9 GPCR/G Protein S1P Receptor ACT 334441 ACT-334441 ACT334441 inhibitor inhibit