carcinoma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1892	Kobe2602		Raf , Ras
	Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.		Raf , Ras
T3020	Sclareol		Apoptosis , Others
	Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.		Apoptosis , Others
T26046	Razoxane		Topoisomerase
	Razoxane is used as an antimitotic agent with immunosuppressive properties.		Topoisomerase
T9693	TBAP-001		Raf
	TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.		Raf
T11363	Ganoderic acid F		Others
	Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium si...		Others
T3862	Irigenin		NF-κB , Integrin
	Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enha...		NF-κB , Integrin
T8344	CPTH2		Apoptosis , Histone Acetyltransferase
	CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.		Apoptosis , Histone Acetyltransferase
T6683	STF-62247	STF 62247	Estrogen/progestogen Receptor , Autophagy
	STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.		Estrogen/progestogen Receptor , Autophagy
T26889	Borofalan(10B)	L-4-Boronophenylalanine	Others
	Borofalan(10B) (L-4-Boronophenylalanine) echibits antineoplastic effects. Borofalan can be used in studies on recurrent or locally advanced head and neck cancer.		Others
T2786	Oxysophocarpine		Prostaglandin Receptor
	Oxysophocarpine is extracted from Sophra flavescens Ait.		Prostaglandin Receptor
T2282	RPI-1		Others , Phospholipase , c-Met/HGFR , c-RET
	RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.		Others , Phospholipase , c-Met/HGFR , c-RET
T8843	APS6-45		MAPK , Ras
	APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.		MAPK , Ras
T23372	SMIFH2		Others
	SMIFH2 is formin homology 2 (FH2) domains inhibitor.		Others
T15371	Gardiquimod		TLR , HIV Protease
	Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells...		TLR , HIV Protease
T5521	Bropirimine	U-54461	TLR
	Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.		TLR
T2676	PF-04217903		c-Met/HGFR
	MET Tyrosine Kinase Inhibitor PF-04217903 is an orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity.		c-Met/HGFR
T1753	D-64131		Microtubule Associated
	D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.		Microtubule Associated
T22661	CHM-1		Apoptosis , Others , Microtubule Associated
	CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.		Apoptosis , Others , Microtubule Associated
T12695	RBN-2397		PARP
	RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.		PARP
T6932	PD168393		Apoptosis , EGFR , FGFR , IGF-1R , PDGFR , PKC , Autophagy
	PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.		Apoptosis , EGFR , FGFR , IGF-1R , PDGFR , PKC , Autophagy