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Sclareol

Catalog No. T3020 CAS 515-03-7

Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.

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Sclareol, CAS 515-03-7

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 35.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.58%

Purity: 99.5%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.
In vitro	Ingestion of Sclareol in rats demonstrates an LD50 greater than 5 g/kg.
In vivo	Sclareol inhibits DNA synthesis in human breast cancer cell lines, inducing apoptosis that does not depend on p53 and causing cell cycle arrest at the G(0/1) phase. Intratumoral injection of Sclareol decreases in-vivo growth of breast cancer tumors. It demonstrates growth inhibition and cytotoxicity across various human cancer cell lines. Additionally, Sclareol exhibits anti-inflammatory activity in lipopolysaccharide-stimulated macrophages by reducing the expression of inflammatory cytokines and increasing the activity of antioxidant enzymes.
Source	Natural Products > Lamiaceae > Salvia

Molecular Weight	308.5
Formula	C20H36O2
CAS No.	515-03-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 57 mg/mL (184.8 mM)

Ethanol: 23 mg/mL (74.6 mM)

References and Literature

1. Dimas K, et al. Biomed Pharmacother, 2006, 60(3), 127-133. 2. Noori S, et al. Cell Immunol, 2010, 263(2), 148-153. 3. Huang GJ, et al. J Nat Prod, 2012, 75(1), 54-59. 4. Sashidhara KV, et al. Phytother Res, 2007, 21(11), 1105-1108. 5. Chen Q, Tang K, Guo Y. Discovery of sclareol and sclareolide as filovirus entry inhibitors[J]. Journal of Asian Natural Products Research. 2020, 22(5): 464-473. 6. Chen Q, Tang K, Guo Y. Discovery of sclareol and sclareolide as filovirus entry inhibitors[J]. Journal of Asian natural products research. 2019: 1-10.

Citations

1. Yang N, Zou C, Luo W, et al. Sclareol attenuates angiotensin II‐induced cardiac remodeling and inflammation via inhibiting MAPK signaling. Phytotherapy Research. 2022 2. Chen Q, Tang K, Guo Y. Discovery of sclareol and sclareolide as filovirus entry inhibitors. Journal of Asian Natural Products Research. 2019: 1-10 3. Chen Q, Tang K, Guo Y. Discovery of sclareol and sclareolide as filovirus entry inhibitors. Journal of Asian Natural Products Research. 2019: 1-10 4. Zhou M, Jiao Q, Wu Z, et al.Uncovering the Oxidative Stress Mechanisms and Targets in Alzheimer’s Disease by Integrating Phenotypic Screening Data and Polypharmacology Networks.Journal of Alzheimer's Disease.2023 (Preprint): 1-18.

Related compound libraries

This product is contained In the following compound libraries：

Tobacco Monomer Library Traditional Chinese Medicine Monomer Library Food as Medicine Compound Library RO5 Drug-like Natural Product Library Hematonosis Compound Library Traditional Mongolian Medicine Compound Library Food Additive Library Apoptosis Compound Library Bioactive Compounds Library Max Human Endogenous Metabolite Compound Library Plus

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Keywords

Sclareol 515-03-7 Apoptosis Others P-388 inhibit Salvia sclarea human epidermal?carcinoma? Inhibitor leukemia cell inhibitor

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