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APS6-45

Catalog No. T8843 CAS 2188236-41-9

APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.

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APS6-45, CAS 2188236-41-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 74.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 528.00
50 mg	In stock	$ 769.00
100 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 218.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
In vitro	APS6-45 (1 μM; 1 h) strongly inhibits RAS pathway activity signaling in human MTC cell lines TT and MZ-CRC-1[1].
In vivo	APS6-45 did not affect body weight of dosed(10 mg/kg) mice after 30 d.APS6-45 (0.1-160 mg/kg; a single p.o.) does not cause detectable toxic effects in mice[1].

Molecular Weight	548.39
Formula	C23H16F8N4O3
CAS No.	2188236-41-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 240mg/mL (437.67mM)

References and Literature

1. Sonoshita M, Scopton AP, Ung PMU, et al. A whole-animal platform to advance a clinical kinase inhibitor into new disease space. Nat Chem Biol. 2018;14(3):291-298. doi:10.1038/nchembio.2556

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Kinase Inhibitor Library GPCR Compound Library Cytoskeletal Signaling Pathway Compound Library Neural Regeneration Compound Library NO PAINS Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library MAPK Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

APS6-45 2188236-41-9 GPCR/G Protein MAPK Ras calibrated signaling TCI Inhibitor APS-6-45 APS645 Carcinoma Thyroid antitumor Medullary APS6 45 tumor inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.