autophagic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5S1099	Liensinine		Apoptosis , Mitophagy , Others , Autophagy
	1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.		Apoptosis , Mitophagy , Others , Autophagy
T9541	CTB	Cholera Toxin B subunit	Epigenetic Reader Domain
	CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.		Epigenetic Reader Domain
T18968	Dansylcadaverine	Monodansyl cadaverine	Others , Autophagy
	Dansylcadaverine (Monodansyl cadaverine) is a fluorescent probe.		Others , Autophagy
T8322	BL-918		Autophagy
	BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.		Autophagy
T7882	Indomethacin farnesil	Infree	Others , COX , Autophagy
	Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD).		Others , COX , Autophagy
T41286	N6-Isopentenyladenosine		Endogenous Metabolite , Autophagy
	N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity. N6-Isopentenyladenosine, an RNA modification found in cytokinins, regulates plant growth/different...		Endogenous Metabolite , Autophagy
T1434	Clarithromycin	A-56268	P450 , ribosome , MRP , Antibacterial , Antibiotic , Autophagy
	Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif...
T9207	GW406108X	GW108X	Kinesin , Autophagy
	GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux.		Kinesin , Autophagy
T5211	NSC 185058	NSC185058	Cysteine Protease , Autophagy
	NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.		Cysteine Protease , Autophagy
T60036	ML-SA5		Autophagy
	ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.		Autophagy
T9583	HJ-PI01	N-Acetylphenoxazine,10-acetylphenoxazine	Pim
	HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.		Pim
T4519	Alisol A	Alisol-A	Autophagy
	Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells).		Autophagy
T11142	EACC		Autophagy
	EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts a...		Autophagy
T5814	Aurantiamide	TMC-58B	p38 MAPK , NF-κB
	Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Aurantiamide has an anti-neuroinflammatory effect on LPS stimula...		p38 MAPK , NF-κB
T1908	MHY1485		mTOR , Autophagy
	MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3II protein and enlarged autophagosomes.		mTOR , Autophagy
TN1721	Gypenoside L		ERK , p38 MAPK , Calcium Channel , NF-κB , ROS
	Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a...		ERK , p38 MAPK , Calcium Channel , NF-κB , ROS
T5S0890	Oleandrin	Neriostene,Folinerin,Foliandrin	Apoptosis , ATPase , Potassium Channel , Sodium Channel
	1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, ...		Apoptosis , ATPase , Potassium Channel , Sodium Channel
T9169	MPP+ iodide		Mitochondrial Metabolism , Autophagy
	MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex...		Mitochondrial Metabolism , Autophagy
T31411	DHA-37	DHA 37
	DHA-37 is an inducer of autophagic cell death through upregulation of HMGB1 in A549 cells.
T26938	CAA0225	CAA 0225,CAA-0225
	CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.