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Aurantiamide

Catalog No. T5814   CAS 58115-31-4
Synonyms: TMC-58B

Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Aurantiamide has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-κB, JNK and p38 pathways.

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Aurantiamide Chemical Structure
Aurantiamide, CAS 58115-31-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 168.00
5 mg In stock $ 416.00
10 mg In stock $ 618.00
25 mg In stock $ 985.00
50 mg In stock $ 1,330.00
100 mg In stock $ 1,790.00
1 mL * 10 mM (in DMSO) In stock $ 550.00
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Purity: 98%
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Biological Description
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Description Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Aurantiamide has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-κB, JNK and p38 pathways.
In vitro Aurantiamide was shown to block the activation of nuclear factor-kappa B (NF-κB) in lipopolysaccharide (LPS)-induced BV2 microglial cells by inhibiting the phosphorylation of the inhibitor kappa B-α (IκB)-α. Aurantiamide decreased the phosphorylation levels of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases (MAPKs).Suggested that aurantiamide has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-κB, JNK and p38 pathways[1].Aurantiamide has potent anti-viral and anti-inflammatory effects on IAV-infected cells via inhibition of the NF-κB pathway. Therefore ,Aurantiamide could be a potential therapeutic agent for the treatment of influenza[2].
Cell Research The anti-viral activity of aurantiamide against Influenza A virus (IAV) was determined using the cytopathic effect (CPE) inhibition assay.?Viruses were titrated on Madin-Darby canine kidney (MDCK) cells by plaque assays.?Ribonucleoprotein (RNP) luciferase reporter assay was further conducted to investigate the effect of aurantiamide on the activity of the viral polymerase complex.?HEK293T cells with a stably transfected NF-κB luciferase reporter plasmid were employed to examine the activity of aurantiamide on NF-κB activation.?Activation of the host signaling pathway induced by IAV infection in the absence or presence of aurantiamide was assessed by western blotting.?The effect of aurantiamide on IAV-induced expression of pro-inflammatory cytokines was measured by real-time quantitative PCR and Luminex assays[2].
Source
Synonyms TMC-58B
Molecular Weight 402.49
Formula C25H26N2O3
CAS No. 58115-31-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (124.22 mM)

TargetMolReferences and Literature

1. Yoon C S , Kim D C , Lee D S , et al. Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: Inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells[J]. International Immunopharmacology, 2014, 23(2):568-574. 2. Zhou B , Yang Z , Feng Q , et al. Aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the NF-κB signaling pathway in Influenza A virus-infected cells[J]. Journal of Ethnopharmacology, 2017, 199:60-67.

Related compound libraries

This product is contained In the following compound libraries:
Marine Natural Product Library Anti-Cancer Active Compound Library Anti-Fibrosis Compound Library Bioactive Compounds Library Max HIF-1 Signaling Pathway Compound Library Osteogenesis Compound Library NF-κB Signaling Compound Library Selected Plant-Sourced Compound Library Traditional Chinese Medicine Monomer Library Oxidation-Reduction Compound Library

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Keywords

Aurantiamide 58115-31-4 MAPK NF-Κb p38 MAPK NF-κB Inhibitor TMC-58B antiplatelet antitumor anti-inflammatory antioxidant inhibit inhibitor

 

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