antiangiogenic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T79364	Antiangiogenic agent 4		Akt
	Compound 3b, an antiangiogenic agent, inhibits Akt phosphorylation in both HFF and HUVEC cells and is utilized in cancer research [1].		Akt
T72363	Antiangiogenic agent 3
	Antiangiogenic agent 3 is a potent inhibitor of human umbilical vein endothelial cells (HUVEC), effectively blocking HUVEC migration and chemotactic motilities. Additionally, it suppresses the gene expression of Src, cdc...
T62931	Antiangiogenic agent 2
	Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.
TN1112	Morellic acid		Others
	Morellic acid has anti-cancer activity, it strongly inhibited the migration of HUVEC at a low concentration of 0.5 μM in HUVEC cell migration assay in vitro. Morellic acid also has antiangiogenic activity.		Others
T3776	Rhapontigenin	Protigenin	P450 , Antibacterial , Antifungal
	Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. R...		P450 , Antibacterial , Antifungal
T21593	AAL-993		VEGFR
	AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogeni...		VEGFR
T29797	AKB-6899	AKB6899	VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
	AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in...		VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
T8742	G5-7	JAK2 inhibitor G5-7	Apoptosis , JAK
	JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) is an orally active JAK2 inhibitor, selectively inhibits JAK2–mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for g...		Apoptosis , JAK
T1011	Itraconazole	R51211	P450 , Hedgehog/Smoothened , Antibiotic , Autophagy , Antifungal
	Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
T6027	Delanzomib	CEP-18770	Apoptosis , NF-κB , Proteasome
	Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome (IC50: 3.8 nM). It only marginally inhibits the tryptic and peptidylglutamyl activities of the proteosome.		Apoptosis , NF-κB , Proteasome
T1335	Mycophenolic acid	Mycophenolate,RS-61443	Apoptosis , Dehydrogenase , Endogenous Metabolite , Antibacterial , Antibiotic , UGT , Antifungal
	Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
T1792L	Regorafenib monohydrate		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect...		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T41003	KG5		Raf , FLT , PDGFR , c-Kit
	KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer and antiangiogenic activities.		Raf , FLT , PDGFR , c-Kit
T3289	Amifostine	Ethyol,WR2721,Gammaphos	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.		Others , HIF/HIF Prolyl-Hydroxylase
T6381	Amifostine trihydrate	Ethyol trihydrate,WR2721,Amifostine	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.		Others , HIF/HIF Prolyl-Hydroxylase
T21334	Bucillamine	DE-019,Thiobutarit,Tiobutarit,SA96,DE 019,DE019	VEGFR , Antioxidant
	Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and...		VEGFR , Antioxidant
T1792	Regorafenib	BAY 73-4506,Fluoro-Sorafenib	Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active. Regorafenib has antitumor and anti-angiogenic activity.		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T2586	Cabozantinib	XL184,BMS-907351	Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit
	Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity...
T5164	Cabozantinib hydrochloride	XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351	VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
	Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).		VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
T16545	Pivanex	Pivalyloxymethyl butyrate,AN-9	Apoptosis , HDAC , Bcr-Abl
	Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.		Apoptosis , HDAC , Bcr-Abl