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Itraconazole

Catalog No. T1011   CAS 84625-61-6
Synonyms: R51211

Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.

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Itraconazole Chemical Structure
Itraconazole, CAS 84625-61-6
Pack Size Availability Price/USD Quantity
50 mg In stock $ 34.00
100 mg In stock $ 48.00
200 mg In stock $ 77.00
500 mg In stock $ 178.00
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Purity: 100%
Purity: 99.97%
Purity: 99.68%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
Targets&IC50 CYP3A4:6.1 nM
Synonyms R51211
Molecular Weight 705.63
Formula C35H38Cl2N8O4
CAS No. 84625-61-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.06 mg/mL (10 mM), Sonification is recommended

TargetMolReferences and Literature

1. Isoherranen N, et al. Drug Metab Dispos, 2004, 32(10), 1121-1131. 2. Kim J, et al. Cancer Cell, 2010, 17(4), 388-399. 3. Oakley KL, et al. Antimicrob Agents Chemother, 1997, 41(5), 1124-1126. 4. Zuckerman JM, et al. Infect Control Hosp Epidemiol, 1994, 15(6), 397-410. 5. Leyden J, et al. J Am Acad Dermatol, 1998, 38(5 Pt 3), S42-47. 6. Tsang C C, Tang J Y M, Ye H, et al. Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing[J]. Mycoses. 2020, 63(12): 1283-1298. 7. Tsang C C, Chan K F, Chan W, et al. Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing[J]. Emerging Microbes & Infections. 2020: 1-53.

TargetMolCitations

1. Ma L, Lian Y, Tang J, et al. Identification of the Anti-Fungal Drug Fenticonazole Nitrate as a Novel PPARγ-Modulating Ligand With Good Therapeutic Index: Structure-Based Screening and Biological Validation. Pharmacological Research. 2021: 105860. 2. Quan C, Chen Y, Wang X, et al. Loss of histone lysine methyltransferase EZH2 confers resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Cancer Letters. 2020 3. Tsang C C, Chan K F, Chan W, et al. Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing. Emerging Microbes & Infections. 2021 Dec;10(1):81-96.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Miao medicine Compound Library Inhibitor Library Anti-Cancer Compound Library Anti-Aging Compound Library Autophagy Compound Library Metabolism Compound Library

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Keywords

Itraconazole 84625-61-6 Autophagy GPCR/G Protein Metabolism Microbiology/Virology Stem Cells Hedgehog/Smoothened P450 Antibiotic Antifungal Inhibitor inhibit Fungal R-51211 CYP-450 lanosterol anticancer Triazole Hedgehog ergosterol Cytochrome P450 antiangiogenic R51211 antifungal CYPs 14α-demethylase R 51211 inhibitor

 

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