angiogenic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3803	Specnuezhenide	Nuzhenide,Nuezhenide	Others , NF-κB , Wnt/beta-catenin
	Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t...		Others , NF-κB , Wnt/beta-catenin
T8616	Fasentin	N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide	transporter
	Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) is an inhibitor of GluT1.		transporter
T5194	SPHINX31		Serine/threonin kinase
	SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).		Serine/threonin kinase
T8846	Beta-Escin	B-escin,AESCINE	Immunology/Inflammation related
	beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.		Immunology/Inflammation related
T7541	PTP inhibitor 1	PTP Inhibitor II	Phosphatase
	PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)),with Ki of128 μM.		Phosphatase
T0724	Formononetin	Biochanin B,Flavosil,Formononetol	Apoptosis , FGFR
	Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.		Apoptosis , FGFR
T1939	DMOG	Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine	HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
	DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.		HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
T2S1200	Sinapine		Antioxidant , P-gp , AChE
	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.		Antioxidant , P-gp , AChE
T3392	Sinapine thiocyanate		P-gp , AChE
	Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...		P-gp , AChE
T7057	Methylstat		Histone Demethylase , Others
	Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD...		Histone Demethylase , Others
T2961	Notoginsenoside R1	Sanqi glucoside R1,Sanchinoside R1	Apoptosis , ERK , Beta Amyloid
	Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.		Apoptosis , ERK , Beta Amyloid
T2160	Suramin Sodium Salt	BAY-205,Suramin hexasodium salt,NF-060	Apoptosis , Phosphatase , SARS-CoV , Sirtuin , Reverse Transcriptase , Topoisomerase , Parasite
	Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth f...
T62931	Antiangiogenic agent 2
	Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.
T79364	Antiangiogenic agent 4		Akt
	Compound 3b, an antiangiogenic agent, inhibits Akt phosphorylation in both HFF and HUVEC cells and is utilized in cancer research [1].		Akt
T72363	Antiangiogenic agent 3
	Antiangiogenic agent 3 is a potent inhibitor of human umbilical vein endothelial cells (HUVEC), effectively blocking HUVEC migration and chemotactic motilities. Additionally, it suppresses the gene expression of Src, cdc...
T24804	SM27	SM-27,NSC-37204,SM 27,NSC37204	FGFR
	SM27 is a fibroblast growth factor 2 (FGF2) inhibitor with anti-angiogenic activity and can be used to study tumours.		FGFR
T5726	Specneuzhenide	Nuezhenide	Others
	Specneuzhenide (Nuezhenide) is a phenol glycoside isolated from Ligustrum sinense. Specneuzhenide (Nuezhenide) possesses anti-tumor activity,has anti-angiogenic and vision improvement effects.		Others
T28911	Tafetinib	SIM-010603,SIM010603,SIM 010603	Tyrosine Kinases
	Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.		Tyrosine Kinases
T3752	4-Hydroxybenzyl alcohol	4-Methylolphenol,P-Methylolphenol	Apoptosis , Endogenous Metabolite
	4-Hydroxybenzyl alcohol (P-Methylolphenol) exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway. 4-Hydroxybe...		Apoptosis , Endogenous Metabolite
T5648	Purpurin	1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin	MAO , Antibacterial , Antibiotic , Antifungal
	Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities.		MAO , Antibacterial , Antibiotic , Antifungal