Search Result

Search Results for " telomerase "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T13115	Telomerase-IN-2	Telomerase inhibitor 2	Telomerase
	Telomerase-IN-2 (Telomerase inhibitor 2) shows potent inhibitory activity against telomerase by decreasing the expression of dyskerin (IC50: 0.89 µM).		Telomerase
T12009	Telomerase-IN-1		Telomerase
	Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR), which then induces ERS, leading to apopto...		Telomerase
T41290	MST-312	Telomerase Inhibitor IX	Telomerase
	MST-312 (Telomerase Inhibitor IX) is a derivative of green tea epigallocatechin gallate (EGCG). MST-312 is a telomerase inhibitor. MST-312 has research value in cancer, such as multiple myeloma (MM).		Telomerase
T13116	Telomerase-IN-3		Others
	Telomerase-IN-3 is an inhibitor of telomerase.		Others
T72789	Telomerase-IN-4		Apoptosis
	Telomerase-IN-4 is a potent inhibitor of telomerase with antiproliferative properties and induces apoptosis [1].		Apoptosis
T72790	Telomerase-IN-5		Apoptosis
	Telomerase-IN-5 is a potent inhibitor of telomerase with antiproliferative properties, and it induces apoptosis [1].		Apoptosis
T2380	BIBR 1532		Apoptosis , Telomerase
	BIBR 1532 is an effective, specific and non-competitive telomerase inhibitor (IC50: 100 nM, in a cell-free assay).		Apoptosis , Telomerase
T6133	Remodelin hydrobromide	Remodelin,Remodelin HBR	RAAS , Histone Acetyltransferase
	Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.		RAAS , Histone Acetyltransferase
T7409	360A		DNA/RNA Synthesis , Telomerase
	360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).		DNA/RNA Synthesis , Telomerase
T13174	TMPyP4 tosylate	TMP 1363	DNA/RNA Synthesis , Telomerase
	TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.		DNA/RNA Synthesis , Telomerase
T10760	Ceramides Mixture		Telomerase
	Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activ...		Telomerase
T8647	BCH001		DNA/RNA Synthesis
	BCH001 is a specific small-molecule inhibitor of PAPD5.		DNA/RNA Synthesis
T1267	Abacavir	Epzicom,Ziagen,Abacavir sulfate	Apoptosis , HIV Protease , Reverse Transcriptase
	Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.		Apoptosis , HIV Protease , Reverse Transcriptase
T6967	RHPS4	RHPS 4 methosulfate,NSC714187	Apoptosis , Telomerase
	RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar.		Apoptosis , Telomerase
T6367	Abacavir sulfate	Abacavir Hemisulfate,1592U89,ABC sulfate,Ziagen	Apoptosis , HIV Protease , Reverse Transcriptase
	Abacavir sulfate (Ziagen) , a nucleoside analogue, effectively utilize its antiviral activity		Apoptosis , HIV Protease , Reverse Transcriptase
T23819	Braco-19 trihydrochloride	BRAC-O19,BRACO19 hydrochloride,BRACO19 3HCl,BRACO 19,BRACO19 HCl	Telomerase
	Braco-19 trihydrochloride (BRACO19 3HCl) is an inhibitor of telomerase and prevents the capping and catalytic action of telomerase. Braco-19 trihydrochloride inhibits HAdV virus replication.		Telomerase
TP1291	Epithalon TFA (307297-39-8 free base)	Epithalon TFA	Others
	Epithalon TFA (307297-39-8 free base) (Epithalon TFA) is an anti-aging agent and telomerase activator.		Others
T6746	6-Thio-2'-Deoxyguanosine	6-Thio-dG,β-TGdR	Others , DNA/RNA Synthesis
	6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.		Others , DNA/RNA Synthesis
T13504	360A iodide	360 A iodide	Telomerase
	360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay).		Telomerase
T10574	BMVC		Telomerase
	BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM).		Telomerase
T33157	Macrocalin B
	Macrocalin B is a diterpenoid against tumor cell proliferation and telomerase activity.
T25207	CAUE
	CAUE is a telomerase activity inhibitor in NALM-6 human B-cell leukemia cells.
T28942	Telomestatin	SOT 095,GM95,(R)-Telomestatin,GM 95,GM-95
	Telomestatin is an inhibitor of the telomerase, it induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region.
T26872	BMVC4	BMVC 4,BMVC-4
	BMVC4 is a G-quadruplex stabilizer. BMVC4 induces senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity.
T73264	L2H2-6OTD
	L2H2-6OTD, a telomeric inhibitor analogue characterized by containing one to four G-quadruplex binding loops, exhibits telomerase inhibitory activity with an IC 50 value of 15 nM.
T83248	7-Deaza-2′-deoxyguanosine 5′-triphosphate	7-Deaza-2'-dGTP	Telomerase
	7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].		Telomerase
T61679	Abacavir monosulfate
	Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, a...
T35428	β-Rubromycin
	β-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 μM, ...

Compounds

Telomerase-IN-2

T13115

Synonym: Telomerase inhibitor 2

Synonym: Telomerase Inhibitor IX

Target: Apoptosis, Telomerase

Remodelin hydrobromide

T6133

Synonym: Remodelin,Remodelin HBR

Target: RAAS, Histone Acetyltransferase

360A

T7409

Synonym:

Target: DNA/RNA Synthesis, Telomerase

TMPyP4 tosylate

T13174

Synonym: TMP 1363

Target: DNA/RNA Synthesis, Telomerase

Target: DNA/RNA Synthesis

Abacavir

T1267

Synonym: Epzicom,Ziagen,Abacavir sulfate

Target: Apoptosis, HIV Protease, Reverse Transcriptase

RHPS4

T6967

Synonym: RHPS 4 methosulfate,NSC714187

Target: Apoptosis, Telomerase

Abacavir sulfate

T6367

Synonym: Abacavir Hemisulfate,1592U89,ABC sulfate,Ziagen

Target: Apoptosis, HIV Protease, Reverse Transcriptase

Braco-19 trihydrochloride

T23819

Synonym: BRAC-O19,BRACO19 hydrochloride,BRACO19 3HCl,BRACO 19,BRACO19 HCl

Target: Telomerase

Epithalon TFA (307297-39-8 free base)

TP1291

Synonym: Epithalon TFA

Target: Others

6-Thio-2'-Deoxyguanosine

T6746

Synonym: 6-Thio-dG,β-TGdR

Target: Others, DNA/RNA Synthesis

360A iodide

T13504

Synonym: 360 A iodide

Synonym: SOT 095,GM95,(R)-Telomestatin,GM 95,GM-95

Target:

BMVC4

T26872

Synonym: BMVC 4,BMVC-4

7-Deaza-2′-deoxyguanosine 5′-triphosphate

T83248

Synonym: 7-Deaza-2'-dGTP

Cat No.	Product Name	Synonyms	Targets
T5575	Cycloastragenol	Cyclogalegenol,Astramembrangenin	Epigenetic Reader Domain , Telomerase
	Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therape...		Epigenetic Reader Domain , Telomerase
T6S0923	Hypericin	Hypericine,Cyclosan	Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC
	1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL...
T6S0052	Chelerythrine	Toddalin,Broussonpapyrine,Cheleritrine	Apoptosis , BCL , PKC , Autophagy
	1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiprolifera...		Apoptosis , BCL , PKC , Autophagy
T2988	(-)-Epigallocatechin Gallate	Epigallocatechol Gallate,EGCG	Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy
	(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor...
TN1059	Ganoderic acid B		IL Receptor , HIV Protease , JAK , STAT
	Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards therapeutic window of trifluoperazine.Ganoderic acid B has an...		IL Receptor , HIV Protease , JAK , STAT
T2902	Costunolide	Costus lactone,NSC 106404,Costunolid,(+)-Costunolide	Apoptosis , Endogenous Metabolite , Telomerase
	Costunolide (Costus lactone) has anti-inflammatory and anti-oxidant properties and mediates apoptosis.		Apoptosis , Endogenous Metabolite , Telomerase
T27282	Erucin	AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056
	Erucin is a sulforaphane analog found in cruciferous vegtables. Erucin is a telomerase inhibitor. It induces phase II enzyme activity, suppresses cellular proliferation in hepatocellular carcinoma cells, prevents 6-OHDA-...

Natural Products

Cycloastragenol

T5575

Synonym: Cyclogalegenol,Astramembrangenin

Target: Epigenetic Reader Domain, Telomerase

Hypericin

T6S0923

Synonym: Hypericine,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Chelerythrine

T6S0052

Synonym: Toddalin,Broussonpapyrine,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

(-)-Epigallocatechin Gallate

T2988

Synonym: Epigallocatechol Gallate,EGCG

Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy

Ganoderic acid B

TN1059

Synonym:

Target: IL Receptor, HIV Protease, JAK, STAT

Costunolide

T2902

Synonym: Costus lactone,NSC 106404,Costunolid,(+)-Costunolide

Target: Apoptosis, Endogenous Metabolite, Telomerase

Erucin

T27282

Synonym: AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02186	TERT Protein, Human, Recombinant (His)	Human	E. coli
	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic c...
TMPH-02926	TRET Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic c...
TMPH-02185	TEP1 Protein, Human, Recombinant (His)	Human	E. coli
	Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cyt...
TMPY-00518	SBDS Protein, Human, Recombinant (His)	Human	E. coli
	The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disor...
TMPY-00452	SBDS Protein, Mouse, Recombinant (His)	Mouse	E. coli
	The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disor...
TMPJ-01357	NHP2 Protein, Human, Recombinant (His)	Human	E. coli
	NHP2 belongs to the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been organized into 2 families: C/D and H/ACA. NHP2 forms a small ribonucleoprotein part...
TMPH-01089	CBX7 Protein, Human, Recombinant (His)	Human	E. coli
	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex...
TMPH-01832	Human Papilloma Virus type 16 (HPV 16) Protein E6 (E. coli, His)	HPV 16	E. coli
	Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ...
TMPH-01833	Human Papilloma Virus type 16 (HPV 16) Protein E6 (His)	HPV 16	Yeast
	Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ...