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Braco-19 trihydrochloride

Catalog No. T23819 CAS 1177798-88-7

Synonyms: BRAC-O19, BRACO19 hydrochloride, BRACO19 3HCl, BRACO 19, BRACO19 HCl

Braco-19 trihydrochloride (BRACO19 3HCl) is an inhibitor of telomerase and prevents the capping and catalytic action of telomerase. Braco-19 trihydrochloride inhibits HAdV virus replication.

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Braco-19 trihydrochloride Chemical Structure

Braco-19 trihydrochloride, CAS 1177798-88-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 189.00
25 mg	In stock	$ 413.00
50 mg	In stock	$ 679.00
100 mg	In stock	$ 1,130.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Braco-19 trihydrochloride (BRACO19 3HCl) is an inhibitor of telomerase and prevents the capping and catalytic action of telomerase. Braco-19 trihydrochloride inhibits HAdV virus replication.
In vitro	The IC50 for BRACO-19 trihydrochloride (1.0-10 μM) in UXF1138L cells is 2.5 μM, the IC100 is 5 μM. BRACO-19 trihydrochloride (1 μM) dramatically reduces the expression of nuclear hTERT[3]. BRACO-19 trihydrochloride (0-40 μM) dose-dependently decreases the AdV virus growth in eGFP-transinfected HEK 293 cells. BRACO-19 trihydrochloride (0-150 μM) decreases band intensity in an increasing concentration-dependent manner[4].
In vivo	In nude mice established UXF1138LX Xenografts, BRACO-19 trihydrochloride (2 mg/kg; i.p.) significantly inhibits tumor growth and shows marked single-agent antitumor activity. some animals in the group shows complete regressions (5 of 12 tumors)[3].

Synonyms	BRAC-O19, BRACO19 hydrochloride, BRACO19 3HCl, BRACO 19, BRACO19 HCl
Molecular Weight	703.14
Formula	C35H46Cl3N7O2
CAS No.	1177798-88-7

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 19.8 mg/mL (28.2 mM), Sonication is recommended.

References and Literature

1. Fleming AM, et al. Human DNA Repair Genes Possess Potential G-Quadruplex Sequences in Their Promoters and 5'-Untranslated Regions. Biochemistry. 2018 Feb 13;57(6):991-1002. 2. Machireddy B, et al. Probing the Binding Pathway of BRACO19 to a Parallel-Stranded Human Telomeric G-Quadruplex Using Molecular Dynamics Binding Simulation with AMBER DNA OL15 and Ligand GAFF2 Force Fields. J Chem Inf Model. 2017 Nov 27;57(11):2846-2864. 3. Angelika M Burger, et al. The G-quadruplex-interactive Molecule BRACO-19 Inhibits Tumor Growth, Consistent With Telomere Targeting and Interference With Telomerase Function. Cancer Res. 2005 Feb 15;65(4):1489-96. 4. Prativa Majee, et al. Genome-wide Analysis Reveals a Regulatory Role for G-quadruplexes During Adenovirus Multiplication. Virus Res. . 2020 Jul 2;283:197960.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Braco-19 trihydrochloride 1177798-88-7 DNA Damage/DNA Repair Telomerase Braco-19 BRACO19 BRAC-O19 BRACO19 hydrochloride BRACO19 3HCl BRACO19 Hydrochloride BRACO 19 BRACO-19 Hydrochloride BRACO19 HCl Braco-19 Trihydrochloride BRACO 19 Hydrochloride inhibitor inhibit

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