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RHPS4

Catalog No. T6967 CAS 390362-78-4

Synonyms: RHPS 4 methosulfate, NSC714187

RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar.

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RHPS4, CAS 390362-78-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 126.00
50 mg	In stock	$ 239.00
100 mg	In stock	$ 396.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 98.59%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar.
Targets&IC50	Telomerase:0.33 μM (IC50)
In vitro	CP 673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors. In glioblastoma tumors, CP-673451 (33 mg/kg) provides >50% inhibition of PDGFR-β receptor for 4 hours corresponding to an EC50 of 120 ng/mL in plasma at Cmax. In a sponge angiogenesis model, CP-673451 inhibits 70% of PDGF-BB-stimulated angiogenesis at a dose of 3 mg/kg (q.d. ×5, p.o., corresponding to 5.5 ng/mL at Cmax).[1] CP-673451 decreases cell proliferation rate through mechanisms involving reduced phosphorylation of GSK-3α and GSK-3β. In both RD and RUCH2 cultures, CP-673451 impairs rhabdosphere-forming capacity and cell differentiation, causes increased senescence. [2]

Synonyms	RHPS 4 methosulfate, NSC714187
Molecular Weight	458.48
Formula	C22H17F2N2·CH3O4S
CAS No.	390362-78-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 91 mg/mL (198.48 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Phatak P, et al. Br J Cancer. 2007, 96(8):1223-33. 2. Salvati E, et al. J Clin Invest. 2007, 117(11):3236-47.

Citations

1. Wang Z, Deng J, Umer M, et al. RHPS4 shifted the conformation ensemble equilibrium of Tel24 by preferentially stabilizing the (3+ 1) hybrid-2 conformation. RSC Advances. 2022, 12(40): 26011-26015. 2. Gao C, Deng J, Anwar N, et al.Molecular crowding promotes the aggregation of parallel structured G-quadruplexes.International Journal of Biological Macromolecules.2023: 124442.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Apoptosis Compound Library Anti-Cancer Compound Library Bioactive Compound Library Preclinical Compound Library DNA Damage & Repair Compound Library Target-Focused Phenotypic Screening Library Bioactive Compounds Library Max Anti-Aging Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RHPS4 390362-78-4 Apoptosis DNA Damage/DNA Repair Telomerase HT29 RHPS-4 NSC 714187 breast cancer Inhibitor inhibit RHPS 4 methosulfate NSC-714187 M14 PC3 H460 RHPS 4 H2AX CG5 NSC714187 inhibitor

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