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(-)-Epigallocatechin Gallate

Catalog No. T2988 CAS 989-51-5

Synonyms: Epigallocatechol Gallate, EGCG

(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptors. (-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

(-)-Epigallocatechin Gallate Chemical Structure

(-)-Epigallocatechin Gallate, CAS 989-51-5

Pack Size	Availability	Price/USD
50 mg	In stock	$ 43.00
100 mg	In stock	$ 57.00
500 mg	In stock	$ 138.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.43%

Purity: 99.39%

Purity: 99.34%

Purity: 98.08%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptors. (-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells.
In vivo	Epigallocatechol Gallate (5 and 20 mg/kg, p.o.) inhibits the growth of tumor in the subcutaneous orthotopic transplant model[4].
Cell Research	LoVo, SW480, HCT-8, and HT-29 cells are seeded in 96-well plates at a concentration of 5×103?cells; each cell line is totally seeded in the 12 wells. Complete medium is added to the wells, up to 200 μL; the medium contains 0 μg/mL, 10 μg/mL, 20 μg/mL, and 35 μg/mL of epigallocatechol gallate. The inhibition rate=[1 - (absorbance of Epigallocatechol Gallate group - absorbance of control group)/(absorbance of control group - absorbance of blank control group)] × 100.
Source	Natural Products > Fabaceae > Acacia

Synonyms	Epigallocatechol Gallate, EGCG
Molecular Weight	458.37
Formula	C22H18O11
CAS No.	989-51-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (218.16 mM)

H2O: 50 mg/mL (109.08 mM), Sonification is recommended

Ethanol: 45.8 mg/mL (100 mM)

References and Literature

1. Khan N, et al. Cancer Res, 2006, 66(5), 2500-2505. 2. Pae M, et al. Food Funct, 2013, 4(9), 1287-1303. 3. Steinmann J, et al. Br J Pharmacol. 2013 Mar;168(5):1059-1073. 4. Jin H, et al. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. Onco Targets Ther. 2013;6:145-53. 5. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 6. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1.

Citations

1. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT. Oncology Reports. 2021, 45(4): 1-1. 2. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system. Chemistry & Biodiversity. 2021

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Miao medicine Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Inhibitor Library Antiparasitic Natural Product Library Anti-virus Traditional Chinese Medicine Monomer Library Human Endogenous Metabolite Compound Library Plus Food as Medicine Compound Library

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Keywords

(-)-Epigallocatechin Gallate 989-51-5 Apoptosis Autophagy Immunology/Inflammation Metabolism Microbiology/Virology NF-Κb Proteases/Proteasome HIV Protease Mitochondrial Metabolism Endogenous Metabolite Ferroptosis Reactive Oxygen Species ( ) Epigallocatechin Gallate Epigallocatechin Gallate inhibit FB-2 cells Epigallocatechol Gallate Inhibitor colorectal cancer LPS-induced bone resorption cell proliferation. EGCG Thyroid cancer ()Epigallocatechin Gallate inhibitor

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