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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TQ0184 | Chebulinic acid | ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad | |
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. | |||
T1748 | Kartogenin | KGN | TGF-beta/Smad |
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. | |||
T4283 | SRI-011381 | TGF-beta/Smad | |
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease. | |||
T13741 | Isoviolanthin | Others | |
Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat... | |||
T2754 | Oxymatrine | Oxysophoridine,Matrine N-oxide | Influenza Virus , Autophagy , TGF-beta/Smad |
Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis B virus.It can also inhibit iNOS expressio... | |||
T16708 | R-268712 | ALK , TGF-beta/Smad | |
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor. | |||
T1449 | Hydrochlorothiazide | HCTZ | Potassium Channel , Carbonic Anhydrase , TGF-beta/Smad |
Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis. | |||
T3636 | (E)-SIS3 | SIS3,SIS3 HCl | TGF-beta/Smad |
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas... | |||
T5129 | SRI-011381 hydrochloride | SRI-011381 hydrochloride [1629138-41-5(free base)] | TGF-beta/Smad |
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease. | |||
T5125 | LY3200882 | TGF-beta/Smad | |
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). | |||
T2896 | Alantolactone | helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,Inula camphor | Apoptosis , STAT , TGF-beta/Smad |
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3... | |||
T6856 | Halofuginone | Tempostatin,empostatin,RU-19110 | Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal. | |||
T5247 | Trimethylamine N-oxide dihydrate | TMANO Dihydrate | Others , Endogenous Metabolite |
Trimethylamine N-oxide dihydrate (TMANO Dihydrate), a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays. | |||
T2386 | Pirfenidone | S-7701,AMR-69,S-7701,AMR69 | CCR , TGF-beta/Smad |
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tum... | |||
T7799 | BMP signaling agonist sb4 | SB 4 | TGF-beta/Smad |
BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM) | |||
T3524 | Halofuginone hydrobromide | Tempostatin,RU-19110 (hydrobromide),Stenorol | Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... | |||
T6496 | Vactosertib | TEW-7197,EW-7197 | ALK , TGF-beta/Smad |
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia... | |||
T3025 | Asiaticoside | BRN0078195,CCRIS8995,Emdecassol,Ba 2742,Madecassol,NSC166062 | Apoptosis , p38 MAPK , Reactive Oxygen Species , Endogenous Metabolite , TGF-beta/Smad |
Asiaticoside (Emdecassol) (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns. | |||
T74204 | Trabedersen | ||
Trabedersen (AP 12009), an antisense oligodeoxynucleotide, specifically targets and inhibits TGF-β2 (TGF-beta/Smad), making it useful for researching malignant brain tumors and other solid tumors with high TGF-β2 express... | |||
T3689L | Ruboxistaurin mesylate | LY-333531,LY333531,LY 333531,LY-333531 Mesylate | |
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic ne... |