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Search Results for " tgf-beta/smad "

20

Compounds

Cat No. Product Name Synonyms Targets
TQ0184 Chebulinic acid ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T1748 Kartogenin KGN TGF-beta/Smad
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
T4283 SRI-011381 TGF-beta/Smad
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
T13741 Isoviolanthin Others
Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat...
T2754 Oxymatrine Oxysophoridine,Matrine N-oxide Influenza Virus , Autophagy , TGF-beta/Smad
Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis B virus.It can also inhibit iNOS expressio...
T16708 R-268712 ALK , TGF-beta/Smad
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.
T1449 Hydrochlorothiazide HCTZ Potassium Channel , Carbonic Anhydrase , TGF-beta/Smad
Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
T3636 (E)-SIS3 SIS3,SIS3 HCl TGF-beta/Smad
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas...
T5129 SRI-011381 hydrochloride SRI-011381 hydrochloride [1629138-41-5(free base)] TGF-beta/Smad
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
T5125 LY3200882 TGF-beta/Smad
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
T2896 Alantolactone helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,Inula camphor Apoptosis , STAT , TGF-beta/Smad
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3...
T6856 Halofuginone Tempostatin,empostatin,RU-19110 Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T5247 Trimethylamine N-oxide dihydrate TMANO Dihydrate Others , Endogenous Metabolite
Trimethylamine N-oxide dihydrate (TMANO Dihydrate), a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays.
T2386 Pirfenidone S-7701,AMR-69,S-7701,AMR69 CCR , TGF-beta/Smad
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tum...
T7799 BMP signaling agonist sb4 SB 4 TGF-beta/Smad
BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)
T3524 Halofuginone hydrobromide Tempostatin,RU-19110 (hydrobromide),Stenorol Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T6496 Vactosertib TEW-7197,EW-7197 ALK , TGF-beta/Smad
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia...
T3025 Asiaticoside BRN0078195,CCRIS8995,Emdecassol,Ba 2742,Madecassol,NSC166062 Apoptosis , p38 MAPK , Reactive Oxygen Species , Endogenous Metabolite , TGF-beta/Smad
Asiaticoside (Emdecassol) (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns.
T74204 Trabedersen
Trabedersen (AP 12009), an antisense oligodeoxynucleotide, specifically targets and inhibits TGF-β2 (TGF-beta/Smad), making it useful for researching malignant brain tumors and other solid tumors with high TGF-β2 express...
T3689L Ruboxistaurin mesylate LY-333531,LY333531,LY 333531,LY-333531 Mesylate
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic ne...

Compounds

Chebulinic acid
TQ0184
Synonym:
Target: ATPase, Proton pump, DNA/RNA Synthesis, Antibacterial, TGF-beta/Smad
Kartogenin
T1748
Synonym: KGN
Target: TGF-beta/Smad
SRI-011381
T4283
Synonym:
Target: TGF-beta/Smad
Isoviolanthin
T13741
Synonym:
Target: Others
Oxymatrine
T2754
Synonym: Oxysophoridine,Matrine N-oxide
Target: Influenza Virus, Autophagy, TGF-beta/Smad
R-268712
T16708
Synonym:
Target: ALK, TGF-beta/Smad
Hydrochlorothiazide
T1449
Synonym: HCTZ
Target: Potassium Channel, Carbonic Anhydrase, TGF-beta/Smad
(E)-SIS3
T3636
Synonym: SIS3,SIS3 HCl
Target: TGF-beta/Smad
SRI-011381 hydrochloride
T5129
Synonym: SRI-011381 hydrochloride [1629138-41-5(free base)]
Target: TGF-beta/Smad
LY3200882
T5125
Synonym:
Target: TGF-beta/Smad
Alantolactone
T2896
Synonym: helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,Inula camphor
Target: Apoptosis, STAT, TGF-beta/Smad
Halofuginone
T6856
Synonym: Tempostatin,empostatin,RU-19110
Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Trimethylamine N-oxide dihydrate
T5247
Synonym: TMANO Dihydrate
Target: Others, Endogenous Metabolite
Pirfenidone
T2386
Synonym: S-7701,AMR-69,S-7701,AMR69
Target: CCR, TGF-beta/Smad
BMP signaling agonist sb4
T7799
Synonym: SB 4
Target: TGF-beta/Smad
Halofuginone hydrobromide
T3524
Synonym: Tempostatin,RU-19110 (hydrobromide),Stenorol
Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Vactosertib
T6496
Synonym: TEW-7197,EW-7197
Target: ALK, TGF-beta/Smad
Asiaticoside
T3025
Synonym: BRN0078195,CCRIS8995,Emdecassol,Ba 2742,Madecassol,NSC166062
Target: Apoptosis, p38 MAPK, Reactive Oxygen Species, Endogenous Metabolite, TGF-beta/Smad
Trabedersen
T74204
Synonym:
Target:
Ruboxistaurin mesylate
T3689L
Synonym: LY-333531,LY333531,LY 333531,LY-333531 Mesylate
Target:
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TargetMol