Search Result

Search Results for " survivin "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
TP2292	survivin (baculoviral IAP repeat-containing protein 5) (21-28)		Others
	Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibitions of apoptosis and mitosis regulation1. Survivin is one of the...		Others
T11383	GDP366		Survivin
	GDP366, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. a dual inhibitor of survivin and Op18.		Survivin
T8469	LQZ-7I		Survivin
	LQZ-7I is an inhibitor of surviving-targeting. It orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors		Survivin
T83774	Shepherdin TFA	Lys-His-Ser-Ser-Gly-Cys-Ala-Phe-Leu-OH,Survivin (79-87)
	Shepherdin is a synthetic peptide mirroring amino acids 79-87 of human survivin, acting as an inhibitor of the survivin-heat shock protein 90 (Hsp90) interaction. It specifically targets the N-terminal domain of Hsp90, b...
T2111	Sepantronium bromide	YM155	Survivin , Autophagy
	Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.		Survivin , Autophagy
T13410	ZLDI-8		Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related
	ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T22424	1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea		Apoptosis , STAT
	SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular ca...		Apoptosis , STAT
T9945	MNK8	3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione	STAT
	MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].		STAT
T12896L	Shepherdin 79-87 acetate	Shepherdin 79-87 acetate (861224-28-4 free base)	HSP , Survivin
	Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.		HSP , Survivin
T61184	LQZ-7F		Apoptosis , Survivin
	LQZ-7F is a small molecule survivin dimerisation inhibitor with anticancer activity.LQZ-7F induces proteasome-dependent survivin degradation, mitotic arrest, and apoptosis, and blocks human tumour growth in mouse xenogra...		Apoptosis , Survivin
T77701	FL118	FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin	Survivin
	FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin s...		Survivin
T3708	BP-1-102		STAT
	BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide interactions and Stat3 activation (4-6.8 μM), and selectively inhi...		STAT
T15137	DK419		Wnt/beta-catenin , AMPK
	DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.		Wnt/beta-catenin , AMPK
T35610	2,5-dimethyl Celecoxib		Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor
	2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ...		Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor
T21834	YM-155 hydrochloride
	Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant that inhibits survivin promoter with an IC 50 of 0.54 nM[1].
T25746	LLP6	LLP 6,LLP-6
	LLP6 is used as a survivin modulator.
T26832	BKM1740	BKM-1740,BKM 1740
	BKM1740 induced apoptosis in prostate cancer (PCa) cells by repressing survivin at both the mRNA and protein levels in vitro.
T71925	Isonanangenine B
	Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B ...
T69840	MX106
	MX106 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.
T70733	APX2009
	APX2009 is a second-generation APE1/Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell prolifer...
T12896	Shepherdin (79-87)	Shepherdin 79-87	Others
	Shepherdin 79-87, comprising amino acids 79 to 87 of Shepherdin, acts as a peptidomimetic antagonist targeting the Hsp90-Survivin complex, exhibiting anticancer properties.		Others
T38414	NSC 80467
	NSC 80467, a selective DNA damaging agent, functions by inhibiting survivin. Specifically, it preferentially targets DNA synthesis, leading to the induction of two distinct markers of DNA damage, namely γH2AX and pKAP1.
T69845	MX107
	MX107 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.
T35542	LLP-3
	Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a ...
T70988	Ibulocydine
	Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomo...
T35729	Nemadipine-A
	Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in...
T61030	STAT3-IN-11		Apoptosis , STAT
	STAT3-IN-11 is a selective STAT3 inhibitor with inhibitory effects on phosphorylation of the STAT3pTyr705 site and phosphorylation of Survivin.STAT3-IN-11 promotes apoptosis in cancer cells and is a candidate compound fo...		Apoptosis , STAT

Compounds

survivin (baculoviral IAP repeat-containing protein 5) (21-28)

Synonym: Lys-His-Ser-Ser-Gly-Cys-Ala-Phe-Leu-OH,Survivin (79-87)

Target: Survivin, Autophagy

ZLDI-8

T13410

Synonym:

Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

T22424

Synonym:

Target: Apoptosis, STAT

MNK8

T9945

Synonym: 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione

Target: STAT

Shepherdin 79-87 acetate

T12896L

Synonym: Shepherdin 79-87 acetate (861224-28-4 free base)

Target: HSP, Survivin

LQZ-7F

T61184

Synonym:

Target: Apoptosis, Survivin

FL118

T77701

Synonym: FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin

Target: Wnt/beta-catenin, AMPK

2,5-dimethyl Celecoxib

T35610

Synonym:

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Synonym: BKM-1740,BKM 1740

Synonym: Shepherdin 79-87

Target: Apoptosis, STAT

Cat No.	Product Name	Synonyms	Targets
T8213	Isolinderalactone		NOS , STAT
	Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.		NOS , STAT
T3S1471	Cucurbitacin IIA	Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis , Survivin
	1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ...		Apoptosis , Survivin

Natural Products

Synonym: Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Target: Apoptosis, Survivin

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03672	Survivin Protein, Human, Recombinant	Human	E. coli
	BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-...
TMPK-01516	HLA-A02:01&B2M&Survivin* (LMLGEFLKL) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293
	Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upreg...
TMPK-01517	HLA-A02:01&B2M&Survivin* (LMLGEFLKL) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293
	Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upreg...
TMPK-01487	HLA-A24:02&B2M&Survivin* 2B (AYACNTSTL) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293
	Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell de...
TMPK-01480	HLA-A02:01&B2M&Survivin* (LMLGEFLKL) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293
	Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upreg...
TMPK-01486	HLA-A24:02&B2M&Survivin* 2B (AYACNTSTL) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293
	Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell de...
TMPK-01481	HLA-A24:02&B2M&Survivin* 2B (AYACNTSTL) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293
	Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell de...
TMPH-00992	BIRC5 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	BIRC5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-02532	BIRC5 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation durin...
TMPH-02533	BIRC5 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation durin...
TMPY-05800	IKB beta/NFKBIB Protein, Human, Recombinant (GST)	Human	E. coli
	NFKBIB (NFKB Inhibitor Beta) is a Protein Coding gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Phosphory...
TMPY-01216	XIAP Protein, Human, Recombinant (Avi)	Human	E. coli
	E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor pr...
TMPY-02922	XIAP Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor pr...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...
TMPH-01616	LRP2 Protein, Human, Recombinant (mFc)	Human	HEK293
	Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins. Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B. In the...