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Cucurbitacin IIA

Catalog No. T3S1471 CAS 58546-34-2

Synonyms: Dihydrocucurbitacin Q1, 葫芦素Iia, Curcurbitacin IIA, Hemslecin A

1. Cucurbitacin IIA can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3.

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Cucurbitacin IIA, CAS 58546-34-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Dihydrocucurbitacin Q1, 葫芦素Iia, Curcurbitacin IIA, Hemslecin A
Molecular Weight	562.744
Formula	C32H50O8
CAS No.	58546-34-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 91 mg/mL(161.7 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. He J , Wang Y , Xu L H , et al. Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages[J]. International Immunopharmacology, 2013, 16(1):27-34.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Terpene Natural Product Library Traditional Chinese Medicine Monomer Library Anti-Pancreatic Cancer Compound Library Natural Product Library for HTS Anti-Tumor Natural Product Library Immunology/Inflammation Compound Library Anti-Cancer Active Compound Library Apoptosis Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cucurbitacin IIA 58546-34-2 凋亡 Apoptosis Survivin Inhibitor inhibit Curcurbitacin IIA Dihydrocucurbitacin Q1 Hemslecin A inhibitor

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