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Sepantronium bromide

Catalog No. T2111 CAS 781661-94-7

Synonyms: YM155

Sepantronium Bromide is a small-molecule proapoptotic agent with potential antineoplastic activity.

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Sepantronium bromide, CAS 781661-94-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sepantronium Bromide is a small-molecule proapoptotic agent with potential antineoplastic activity.
Targets&IC50	Survivin:0.54 nM
Kinase Assay	Promoter-luciferase reporter assay: A 2,767-bp sequence of human survivin gene promoter is isolated from human genomic DNA by PCR using Pyrobest polymerase and the following primers: 5
Cell Research	Cells are seeded in 96-well plates at a density of 5-40 × 103. YM155 is dissolved in DMSO and added to cells for 48 hours. Then the cell count is determined by sulforhodamine B assay. (Only for Reference)

Synonyms	YM155
Molecular Weight	443.301
Formula	C20H19BrN4O3
CAS No.	781661-94-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 82 mg/mL (185 mM)

Ethanol: 6 mg/mL (13.53 mM)

DMSO: 51 mg/mL (115.1 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Nakahara T, et al. Cancer Res, 2007, 67(17), 82014-8021. 2. Iwasa T, et al. Clin Cancer Res, 2008, 14(20), 6496-6504.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Anti-Lung Cancer Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-COVID-19 Compound Library Anti-Breast Cancer Compound Library Apoptosis Compound Library Anti-Cancer Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sepantronium bromide 781661-94-7 凋亡自噬 Autophagy Survivin inhibit Inhibitor YM-155 Sepantronium YM 155 YM155 inhibitor

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