Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between HSP90 and Survivin, another key regulator of tumor cell viability.
Description | Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability. |
In vitro | When added to prostate carcinoma (PC3, DU145) or HeLa cells, shepherdin caused concentration-dependent and complete loss of cell viability[1]. |
In vivo | Shepherdin-RV (50 mg/kg, i.p., daily) nearly completely ablated tumor growth in immunocompromised mice prostating carcinoma PC3 cells. In a breast cancer xenograft model that employs MCF-7 cells adapted in vivo, injection of Shepherdin-RV resulted in exponentially growing tumors independently of estrogen supplementation, which was unaffected by saline administration. Shepherdin-RV (50 mg/kg i.p. daily) uniformly inhibited the growth of these more aggressive tumors (p = 0.01) throughout a 23-day or 11-day treatment regimen. Shepherdin treatment resulted in nearly complete loss of Akt levels in tumor cells and severely attenuated expression of survivin[1]. |
Synonyms | Shepherdin 79-87 acetate (861224-28-4 free base) |
Molecular Weight | 1009.14 |
Formula | C43H68N12O14S |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Shepherdin 79-87 acetate Apoptosis Cytoskeletal Signaling Metabolism HSP Survivin Shepherdin 79 87 acetate Shepherdin 79-87 acetate (861224-28-4 free base) Shepherdin 7987 acetate Inhibitor inhibitor inhibit