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Shepherdin 79-87 acetate

Catalog No. T12896L

Synonyms: Shepherdin 79-87 acetate (861224-28-4 free base)

Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between HSP90 and Survivin, another key regulator of tumor cell viability.

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Shepherdin 79-87 acetate, CAS N/A

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.
In vitro	When added to prostate carcinoma (PC3, DU145) or HeLa cells, shepherdin caused concentration-dependent and complete loss of cell viability[1].
In vivo	Shepherdin-RV (50 mg/kg, i.p., daily) nearly completely ablated tumor growth in immunocompromised mice prostating carcinoma PC3 cells. In a breast cancer xenograft model that employs MCF-7 cells adapted in vivo, injection of Shepherdin-RV resulted in exponentially growing tumors independently of estrogen supplementation, which was unaffected by saline administration. Shepherdin-RV (50 mg/kg i.p. daily) uniformly inhibited the growth of these more aggressive tumors (p = 0.01) throughout a 23-day or 11-day treatment regimen. Shepherdin treatment resulted in nearly complete loss of Akt levels in tumor cells and severely attenuated expression of survivin[1].

Synonyms	Shepherdin 79-87 acetate (861224-28-4 free base)
Molecular Weight	1009.14
Formula	C43H68N12O14S

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Plescia J, et al. Rational design of shepherdin, a novel anticancer agent. Cancer Cell. 2005 May;7(5):457-68.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Shepherdin 79-87 acetate Apoptosis Cytoskeletal Signaling Metabolism HSP Survivin Shepherdin 79 87 acetate Shepherdin 79-87 acetate (861224-28-4 free base) Shepherdin 7987 acetate Inhibitor inhibitor inhibit

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