noncompetitive — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12103	MR-L2		PDE
	MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).		PDE
T2013	Ponalrestat		Reductase
	Ponalrestat is an aldose reductase inhibitor.		Reductase
T22748	DQP 1105		NMDAR
	DQP 1105 is a NMDA receptor antagonist.		NMDAR
T9214	ELOVL6-IN-1		Others
	ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner...		Others
T11696	Ivachtin	Caspase-3 Inhibitor VII	Caspase
	Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases.		Caspase
T8461	SKI V		Apoptosis , PI3K , S1P Receptor
	SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity		Apoptosis , PI3K , S1P Receptor
T2694	KN-62		CaMK , P2X Receptor , Autophagy
	KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.		CaMK , P2X Receptor , Autophagy
T6259	Dizocilpine	MK-801	NMDAR , iGluR
	MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.		NMDAR , iGluR
T2463	ML141	CID-2950007	Apoptosis , CDK , Ras
	ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).		Apoptosis , CDK , Ras
T4190	Ticlopidine	PCR 5332,Ticlid	ATPase , Adiponectin receptor
	Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.		ATPase , Adiponectin receptor
T6S2391	L-Chicoric Acid	(-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid	Others , HIV Protease
	L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may ...		Others , HIV Protease
T3320	Dizocilpine Maleate	(+)-Mk-801 Hydrogen Maleate,MK 801,Dizocilpine hydrogen maleate,(+)-MK 801 maleate,(+)-MK 801 (Maleate)	NMDAR , iGluR
	Dizocilpine Maleate (MK 801) is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has been considered for the wide variety of ne...		NMDAR , iGluR
T3444	Merimepodib	VX-497,VI-21497	Dehydrogenase , Antiviral , HCV Protease , HBV
	Merimepodib (VX-497) is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).		Dehydrogenase , Antiviral , HCV Protease , HBV
T23353	(E/Z)-SIB-1893	SIB 1893	Others , GluR
	(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893. (E)-SIB-1893 is a selective, noncompetitive mGluR5 antagonist with anticonvulsant activity .		Others , GluR
T1979	AVN-944	VX-944	Dehydrogenase
	AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.		Dehydrogenase
T71665	INCB-9471
	INCB-9471 is an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5.
T8457	NPS2390		GluR
	NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)		GluR
T22703	CYM-5520	CYM 5520	S1P Receptor , LPL Receptor
	CYM-5520 is a noncompetitive allosteric agonist of S1P2		S1P Receptor , LPL Receptor
TP1888L1	[Ala113]-MBP (104-118) acetate		PKC
	[Ala113]MBP(104-118) acetate is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging from 28-62 μM.		PKC
T3591	URB602		Lipase , Antibacterial
	URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.		Lipase , Antibacterial